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Cardiometabolic predictors of high-risk CCTA phenotype in a diverse patient population

التفاصيل البيبلوغرافية
العنوان: Cardiometabolic predictors of high-risk CCTA phenotype in a diverse patient population
المؤلفون: Toshiki Kuno, Javier Arce, Michael Fattouh, Sharmila Sarkar, John P Skendelas, Jonathan Daich, Aldo L Schenone, Lili Zhang, Carlos J Rodriguez, Salim S Virani, Piotr J Slomka, Leslee J Shaw, Eric E Williamson, Daniel S Berman, Mario J Garcia, Damini Dey, Leandro Slipczuk
المصدر: American Journal of Preventive Cardiology, Vol 15, Iss , Pp 100578- (2023)
بيانات النشر: Elsevier, 2023.
سنة النشر: 2023
المجموعة: LCC:Diseases of the circulatory (Cardiovascular) system
LCC:Public aspects of medicine
مصطلحات موضوعية: High-risk plaque, CT coronary angiogram, Risk factors, PCAT, LAP, Epicardial adipose tissue, Diseases of the circulatory (Cardiovascular) system, RC666-701, Public aspects of medicine, RA1-1270
الوصف: Introduction: Low-attenuation non-calcified plaque (LAP) burden and vascular inflammation by pericoronary adipose tissue (PCAT) measured from coronary CT angiography (CCTA) have shown to be predictors of cardiovascular outcomes. We aimed to investigate the relationships of cardiometabolic risk factors including lipoprotein(a) and epicardial adipose tissue (EAT) with CCTA high-risk imaging biomarkers, LAP and vascular inflammation. Methods: The patient population consisted of consecutive patients who underwent CCTA for stable chest pain and had a complete cardiometabolic panel including lipoprotein(a). Plaque, PCAT and EAT were measured from CT using semiautomated software. Elevated LAP burden and PCAT attenuation were defined as ≥4% and ≥70.5 HU, respectively. The primary clinical end-point was a composite of myocardial infarction, revascularization or cardiovascular death. Results: A total of 364 consecutive patients were included (median age 56 years, 64% female); the majority of patients were of Hispanic (60%), and the rest were of non-Hispanic Black (21%), non-Hispanic White (6%) and non-Hispanic Asian (4%) race/ethnicity. The prevalence of elevated LAP burden and PCAT attenuation was 31 and 18%, respectively, while only 8% had obstructive stenosis. There were significant differences in plaque characteristics among different racial/ethnic groups (p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2666-6677
Relation: http://www.sciencedirect.com/science/article/pii/S2666667723001198; https://doaj.org/toc/2666-6677
DOI: 10.1016/j.ajpc.2023.100578
URL الوصول: https://doaj.org/article/99bcbe62bb5d439ca0f19af55f817afa
رقم الأكسشن: edsdoj.99bcbe62bb5d439ca0f19af55f817afa
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:26666677
DOI:10.1016/j.ajpc.2023.100578