دورية أكاديمية
Identification of Genes Crucial for Biological Processes in Breast Cancer Liver Metastasis Relapse
| العنوان: | Identification of Genes Crucial for Biological Processes in Breast Cancer Liver Metastasis Relapse |
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| المؤلفون: | Tyler Kwok, Suneetha Yeguvapalli, Kumaraswamy Naidu Chitrala |
| المصدر: | International Journal of Molecular Sciences, Vol 25, Iss 10, p 5439 (2024) |
| بيانات النشر: | MDPI AG, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | breast cancer recurrence, breast cancer liver metastasis, bioinformatic analysis, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Breast cancer, when advancing to a metastatic stage, involves the liver, impacting over 50% of cases and significantly diminishing survival rates. Presently, a lack of tailored therapeutic protocols for breast cancer liver metastasis (BCLM) underscores the need for a deeper understanding of molecular patterns governing this complication. Therefore, by analyzing differentially expressed genes (DEGs) between primary breast tumors and BCLM lesions, we aimed to shed light on the diversities of this process. This research investigated breast cancer liver metastasis relapse by employing a comprehensive approach that integrated data filtering, gene ontology and KEGG pathway analysis, overall survival analysis, identification of the alteration in the DEGs, visualization of the protein–protein interaction network, Signor 2.0, identification of positively correlated genes, immune cell infiltration analysis, genetic alternation analysis, copy number variant analysis, gene-to-mRNA interaction, transcription factor analysis, molecular docking, and identification of potential treatment targets. This study’s integrative approach unveiled metabolic reprogramming, suggesting altered PCK1 and LPL expression as key in breast cancer metastasis recurrence. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/25/10/5439; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms25105439 |
| URL الوصول: | https://doaj.org/article/99cd78a7a6234c369872c5a49b2f1835 |
| رقم الأكسشن: | edsdoj.99cd78a7a6234c369872c5a49b2f1835 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms25105439 |