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Utilization of hepatitis B surface antigen-positive donors in liver transplantation for recipients with hepatocellular carcinoma: a retrospective and propensity score matching analysis

التفاصيل البيبلوغرافية
العنوان: Utilization of hepatitis B surface antigen-positive donors in liver transplantation for recipients with hepatocellular carcinoma: a retrospective and propensity score matching analysis
المؤلفون: Zhitao Chen, Yihao Ma, Yuqi Dong, Chuanbao Chen, Hanyu Wang, Tielong Wang, Jia Yu, Xitao Hong, Maogen Chen, Xiaoshun He, Weiqiang Ju
المصدر: PeerJ, Vol 11, p e15620 (2023)
بيانات النشر: PeerJ Inc., 2023.
سنة النشر: 2023
المجموعة: LCC:Medicine
LCC:Biology (General)
مصطلحات موضوعية: Liver transplantation, Propensity score matching, Hepatitis B antigen-positive donor, Hepatocellular carcinoma, Progression-free survival, Overall survival, Medicine, Biology (General), QH301-705.5
الوصف: Introduction The use of extended criteria donor (ECD) grafts such as donor with infection of hepatitis B virus (HBV) is a potential solution for organ shortage. In this study, we aimed to evaluate the safety and long-term survival of utilization of hepatitis B surface antigen-positive (HBsAg+) donor livers in HCC patients using propensity score matching (PSM) analysis. Methods Forty-eight donors with HBsAg-positive and 279 donors with HBsAg-negative were transplanted and enrolled in this study. PSM analysis were used to eliminate selection bias. Perioperative data and survival were collected and analyzed. Results PSM generated 44 patient pairs. When comparing intra- and post-operative data, no significant difference was found between groups (P > 0.05). Patients with a HBsAg-positive donor had significantly worse progression-free survival (1-year: 65.9% vs. 90.9%; 3-year: 18.1% vs. 70.4%, P = 0.0060) and overall survival (1-year: 84.1% and 95.4%; 3-year: 27.2% vs. 79.5%, P = 0.0039). In multivariate analysis, donor HBsAg-positivity was an independent risk factor for survival and occurrence (P = 0.005 and 0.025, respectively). Conclusion In conclusion, with adequate antiviral prophylaxis and treatment, utilization of HBsAg positive liver grafts did not increase the incidence of early-stage complications. However, patient with an HBsAg-positive graft had poorer progression-free survival and overall survival.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2167-8359
Relation: https://peerj.com/articles/15620.pdf; https://peerj.com/articles/15620/; https://doaj.org/toc/2167-8359
DOI: 10.7717/peerj.15620
URL الوصول: https://doaj.org/article/99d220221a2b4f61ae3641ea714d5be7
رقم الأكسشن: edsdoj.99d220221a2b4f61ae3641ea714d5be7
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:21678359
DOI:10.7717/peerj.15620