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Quality by Design-Optimized Glycerosome-Enabled Nanosunscreen Gel of Rutin Hydrate

التفاصيل البيبلوغرافية
العنوان: Quality by Design-Optimized Glycerosome-Enabled Nanosunscreen Gel of Rutin Hydrate
المؤلفون: Md. Shabbir Alam, Niha Sultana, Md. Abdur Rashid, Yahya Alhamhoom, Asad Ali, Ayesha Waheed, Mo. Suheb Ansari, Mohd. Aqil, Mohd Mujeeb
المصدر: Gels, Vol 9, Iss 9, p 752 (2023)
بيانات النشر: MDPI AG, 2023.
سنة النشر: 2023
المجموعة: LCC:Science
LCC:Chemistry
LCC:Inorganic chemistry
LCC:General. Including alchemy
مصطلحات موضوعية: sunburn, rutin, antioxidants, glycerosome, carbopol-gel, DoE, Science, Chemistry, QD1-999, Inorganic chemistry, QD146-197, General. Including alchemy, QD1-65
الوصف: Sunburn is caused by prolonged exposure to ultraviolet (UV) rays from the sun, resulting in redness of the skin as well as tenderness, swelling, and blistering issues. During the healing process, it can cause peeling, irritation, and some long-term effects, including premature aging, pigmentation, and a high risk of skin cancer. Rutin has antioxidant and anti-inflammatory effects, which could potentially reduce inflammation and soothe sunburned skin. The objective of the current proposal is to develop and create carbopol gel-encased glycerosomes for the treatment of sunburn. The Design of Expert (DoE) technique was used to optimize the proposed formulation and was subjected to various characterization parameters such as nanovesicles size, polydispersity index (PDI), surface charge, entrapment efficiency (EE), and surface morphology. The optimized rutin-loaded glycerosomes (opt-RUT-loaded-GMs) were further characterised for drug release, 2,2-Diphenyl-1-picrylhydrazyl (DPPH) assay, and confocal laser scanning microscopy (CLSM). The formulation showed sustained release, greater permeation into the skin, and good antioxidant activity. The dermatokinetic study of opt-RUT-loaded-GMs confirms that the Rutin hydrate had better retention in the epidermis as compared to the dermis, owing to its potential for long lasting protection after topical application. It was observed that the prepared formulation was stable, highly safe, and had good sun protection factor (SPF) values that could be used as a suitable option for topical drug administration to maximize the therapeutic efficacy of the drugs.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2310-2861
Relation: https://www.mdpi.com/2310-2861/9/9/752; https://doaj.org/toc/2310-2861
DOI: 10.3390/gels9090752
URL الوصول: https://doaj.org/article/99d9d8145d5c4966a49c2b4ac9ce54ec
رقم الأكسشن: edsdoj.99d9d8145d5c4966a49c2b4ac9ce54ec
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:23102861
DOI:10.3390/gels9090752