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A window of opportunity to control the bacterial pathogen Pseudomonas aeruginosa combining antibiotics and phages.

التفاصيل البيبلوغرافية
العنوان: A window of opportunity to control the bacterial pathogen Pseudomonas aeruginosa combining antibiotics and phages.
المؤلفون: Clara Torres-Barceló, Flor I Arias-Sánchez, Marie Vasse, Johan Ramsayer, Oliver Kaltz, Michael E Hochberg
المصدر: PLoS ONE, Vol 9, Iss 9, p e106628 (2014)
بيانات النشر: Public Library of Science (PLoS), 2014.
سنة النشر: 2014
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: The evolution of antibiotic resistance in bacteria is a global concern and the use of bacteriophages alone or in combined therapies is attracting increasing attention as an alternative. Evolutionary theory predicts that the probability of bacterial resistance to both phages and antibiotics will be lower than to either separately, due for example to fitness costs or to trade-offs between phage resistance mechanisms and bacterial growth. In this study, we assess the population impacts of either individual or combined treatments of a bacteriophage and streptomycin on the nosocomial pathogen Pseudomonas aeruginosa. We show that combining phage and antibiotics substantially increases bacterial control compared to either separately, and that there is a specific time delay in antibiotic introduction independent of antibiotic dose, that minimizes both bacterial density and resistance to either antibiotics or phage. These results have implications for optimal combined therapeutic approaches.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC4178015?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0106628
URL الوصول: https://doaj.org/article/a99daf4a6b2b4de5bfa7a55630eccc6a
رقم الأكسشن: edsdoj.99daf4a6b2b4de5bfa7a55630eccc6a
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0106628