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Efficacy and safety of low molecular weight heparin compared to unfractionated heparin for chronic outpatient hemodialysis in end stage renal disease: systematic review and meta-analysis

التفاصيل البيبلوغرافية
العنوان: Efficacy and safety of low molecular weight heparin compared to unfractionated heparin for chronic outpatient hemodialysis in end stage renal disease: systematic review and meta-analysis
المؤلفون: Ghanshyam Palamaner Subash Shantha, Anita Ashok Kumar, Mansha Sethi, Rohit C. Khanna, Samir Bipin Pancholy
المصدر: PeerJ, Vol 3, p e835 (2015)
بيانات النشر: PeerJ Inc., 2015.
سنة النشر: 2015
المجموعة: LCC:Medicine
LCC:Biology (General)
مصطلحات موضوعية: Heparin, Hemodialysis, Thromboprophylaxis, Meta-analysis, Medicine, Biology (General), QH301-705.5
الوصف: Background. Low molecular weight heparin (LMWH) is an effective anti-coagulant for thrombotic events. However, due to its predominant renal clearance, there are concerns that it might be associated with increased bleeding in patients with renal disease.Objectives. We systematically evaluated the efficacy and safety of LMWH compared to unfractionated heparin (UH) in end stage renal disease (ESRD) patients.Search Methods. Pubmed, Embase and cochrane central were searched for eligible citations.Selection Criteria. Randomized controlled trials, comparing LMWH and UH, involving adult (age > 18 years), ESRD patients receiving outpatient, chronic, intermittent hemodialysis were included.Data Collection and Analysis. Two independent reviewers performed independent data abstraction. I2 statistic was used to assess heterogeneity. Random effects model was used for meta-analysis.Results. Nineteen studies were included for systematic review and 4 were included for meta-analysis. There were no significant differences between LMWH and UFH for extracorporeal circuit thrombosis [risk ratio: 1 (95% CI [0.62–1.62])] and bleeding complications [risk ratio: 1.16 (95% CI [0.62–2.15])].Conclusions. LMWH is as safe and effective as UFH. Considering the poor quality of studies included for the review, larger well conducted RCTs are required before conclusions can be drawn.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2167-8359
Relation: https://peerj.com/articles/835.pdf; https://peerj.com/articles/835/; https://doaj.org/toc/2167-8359
DOI: 10.7717/peerj.835
URL الوصول: https://doaj.org/article/99eadf62b9014a8f958b5bbc846352ea
رقم الأكسشن: edsdoj.99eadf62b9014a8f958b5bbc846352ea
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:21678359
DOI:10.7717/peerj.835