دورية أكاديمية
Tecovirimat Resistance in Mpox Patients, United States, 2022–2023
| العنوان: | Tecovirimat Resistance in Mpox Patients, United States, 2022–2023 |
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| المؤلفون: | Todd G. Smith, Crystal M. Gigante, Nhien T. Wynn, Audrey Matheny, Whitni Davidson, Yong Yang, Rene Edgar Condori, Kyle O’Connell, Lynsey Kovar, Tracie L. Williams, Yon C. Yu, Brett W. Petersen, Nicolle Baird, David Lowe, Yu Li, Panayampalli S. Satheshkumar, Christina L. Hutson |
| المصدر: | Emerging Infectious Diseases, Vol 29, Iss 12, Pp 2426-2432 (2023) |
| بيانات النشر: | Centers for Disease Control and Prevention, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine LCC:Infectious and parasitic diseases |
| مصطلحات موضوعية: | mpox, viruses, antivirals, tecovirimat, ST-246, TPOXX, Medicine, Infectious and parasitic diseases, RC109-216 |
| الوصف: | During the 2022 multinational outbreak of monkeypox virus (MPXV) infection, the antiviral drug tecovirimat (TPOXX; SIGA Technologies, Inc., https://www.siga.com) was deployed in the United States on a large scale for the first time. The MPXV F13L gene homologue encodes the target of tecovirimat, and single amino acid changes in F13 are known to cause resistance to tecovirimat. Genomic sequencing identified 11 mutations previously reported to cause resistance, along with 13 novel mutations. Resistant phenotype was determined using a viral cytopathic effect assay. We tested 124 isolates from 68 patients; 96 isolates from 46 patients were found to have a resistant phenotype. Most resistant isolates were associated with severely immunocompromised mpox patients on multiple courses of tecovirimat treatment, whereas most isolates identified by routine surveillance of patients not treated with tecovirimat remained sensitive. The frequency of resistant viruses remains relatively low ( |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1080-6040 1080-6059 |
| Relation: | https://wwwnc.cdc.gov/eid/article/29/12/23-1146_article; https://doaj.org/toc/1080-6040; https://doaj.org/toc/1080-6059 |
| DOI: | 10.3201/eid2912.231146 |
| URL الوصول: | https://doaj.org/article/9a123816218646aabeb63e8826093b2a |
| رقم الأكسشن: | edsdoj.9a123816218646aabeb63e8826093b2a |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 10806040 10806059 |
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| DOI: | 10.3201/eid2912.231146 |