دورية أكاديمية
أعرض في EDS

Does fibrin(ogen) bind to monomeric or dimeric GPVI, or not at all?

التفاصيل البيبلوغرافية
العنوان: Does fibrin(ogen) bind to monomeric or dimeric GPVI, or not at all?
المؤلفون: Alexandre Slater, Gina Perrella, Marie-Blanche Onselaer, Eleyna M Martin, Julia S Gauer, Rui-Gang Xu, Johan WM Heemskerk, Robert A S Ariëns, Steve P Watson
المصدر: Platelets, Vol 30, Iss 3, Pp 281-289 (2019)
بيانات النشر: Taylor & Francis Group, 2019.
سنة النشر: 2019
المجموعة: LCC:Diseases of the blood and blood-forming organs
مصطلحات موضوعية: collagen, fibrin(ogen), gpvi, platelets, Diseases of the blood and blood-forming organs, RC633-647.5
الوصف: GPVI is the major signalling receptor for collagen on platelets. Dimerization of GPVI is required for collagen binding and initiation of signalling through the associated FcR-γ chain. Recently, fibrin and fibrinogen have been identified as ligands for GPVI and shown to induce signalling in support of thrombus formation and stabilization. Contrasting observations have been reported on whether fibrin binds to monomeric or dimeric GPVI, or to neither form. In this article, we discuss reasons for the contradictory results and how to reconcile these. We conclude that a lack of structural knowledge regarding the GPVI constructs that are being used, along with the use of non-standardized reagents, might be the main cause of the discrepant results. This article aims to highlight some of the key areas that need to be addressed.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 0953-7104
1369-1635
09537104
Relation: https://doaj.org/toc/0953-7104; https://doaj.org/toc/1369-1635
DOI: 10.1080/09537104.2018.1508649
URL الوصول: https://doaj.org/article/e9a50144d2f442d5bc7eee4bda5fb401
رقم الأكسشن: edsdoj.9a50144d2f442d5bc7eee4bda5fb401
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:09537104
13691635
DOI:10.1080/09537104.2018.1508649