دورية أكاديمية
Pathogenesis of Alkali Injury-Induced Limbal Stem Cell Deficiency: A Literature Survey of Animal Models
| العنوان: | Pathogenesis of Alkali Injury-Induced Limbal Stem Cell Deficiency: A Literature Survey of Animal Models |
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| المؤلفون: | Lina Sprogyte, Mijeong Park, Nick Di Girolamo |
| المصدر: | Cells, Vol 12, Iss 9, p 1294 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Cytology |
| مصطلحات موضوعية: | corneal alkali burn, limbal stem cell deficiency, pathogenesis, Cytology, QH573-671 |
| الوصف: | Limbal stem cell deficiency (LSCD) is a debilitating ocular surface disease that eventuates from a depleted or dysfunctional limbal epithelial stem cell (LESC) pool, resulting in corneal epithelial failure and blindness. The leading cause of LSCD is a chemical burn, with alkali substances being the most common inciting agents. Characteristic features of alkali-induced LSCD include corneal conjunctivalization, inflammation, neovascularization and fibrosis. Over the past decades, animal models of corneal alkali burn and alkali-induced LSCD have been instrumental in improving our understanding of the pathophysiological mechanisms responsible for disease development. Through these paradigms, important insights have been gained with regards to signaling pathways that drive inflammation, neovascularization and fibrosis, including NF-κB, ERK, p38 MAPK, JNK, STAT3, PI3K/AKT, mTOR and WNT/β-catenin cascades. Nonetheless, the molecular and cellular events that underpin re-epithelialization and those that govern long-term epithelial behavior are poorly understood. This review provides an overview of the current mechanistic insights into the pathophysiology of alkali-induced LSCD. Moreover, we highlight limitations regarding existing animal models and knowledge gaps which, if addressed, would facilitate development of more efficacious therapeutic strategies for patients with alkali-induced LSCD. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 12091294 2073-4409 |
| Relation: | https://www.mdpi.com/2073-4409/12/9/1294; https://doaj.org/toc/2073-4409 |
| DOI: | 10.3390/cells12091294 |
| URL الوصول: | https://doaj.org/article/9a542e938e2e48bfa5596f85c7258785 |
| رقم الأكسشن: | edsdoj.9a542e938e2e48bfa5596f85c7258785 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 12091294 20734409 |
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| DOI: | 10.3390/cells12091294 |