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Efficient Syntheses of 1,2,3-Triazoloamide Derivatives Using Solid- and Solution-Phase Synthetic Approaches

التفاصيل البيبلوغرافية
العنوان: Efficient Syntheses of 1,2,3-Triazoloamide Derivatives Using Solid- and Solution-Phase Synthetic Approaches
المؤلفون: Doohyun Lee, Daehun Kim, Seungyeon Lee, Taegeum Kim, Joobin Kim, Sohee Kim, Kwang-Hyeon Liu, Sangkyu Lee, Jong-Sup Bae, Kyung-Sik Song, Chang-Woo Cho, Youn Kyung Son, Dong Jae Baek, Taeho Lee
المصدر: Molecules, Vol 20, Iss 11, Pp 19984-20013 (2015)
بيانات النشر: MDPI AG, 2015.
سنة النشر: 2015
المجموعة: LCC:Organic chemistry
مصطلحات موضوعية: 1,2,3-triazoloamide, solid-phase synthesis, solution-phase synthesis, Organic chemistry, QD241-441
الوصف: Efficient synthetic routes for the preparation of secondary and tertiary 1,2,3-triazoloamide derivatives were developed. A secondary α-1,2,3-triazoloamide library was constructed and expanded by a previously developed solid-phase synthetic route and a tertiary 1,2,3-triazoloamide library was constructed by a parallel solution-phase synthetic route. The synthetic routes rely on amide formation with secondary amines and chloro-acid chlorides; SN2 reaction with sodium azide; and the selective [3 + 2] Hüisgen cycloaddition with appropriate terminal alkynes. The target secondary and tertiary 1,2,3-triazoloamide derivatives were obtained with three-diversity points in excellent overall yields and purities using the reported solid- and solution-phase synthetic routes, respectively.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1420-3049
20111967
Relation: http://www.mdpi.com/1420-3049/20/11/19673; https://doaj.org/toc/1420-3049
DOI: 10.3390/molecules201119673
URL الوصول: https://doaj.org/article/9a8aad86992b4480b6dabd9530e3dfc0
رقم الأكسشن: edsdoj.9a8aad86992b4480b6dabd9530e3dfc0
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14203049
20111967
DOI:10.3390/molecules201119673