دورية أكاديمية
Correlates of Subjective and Mild Cognitive Impairment: Depressive Symptoms and CSF Biomarkers
| العنوان: | Correlates of Subjective and Mild Cognitive Impairment: Depressive Symptoms and CSF Biomarkers |
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| المؤلفون: | Ramune Grambaite, Erik Hessen, Eirik Auning, Dag Aarsland, Per Selnes, Tormod Fladby |
| المصدر: | Dementia and Geriatric Cognitive Disorders Extra, Vol 3, Iss 1, Pp 291-300 (2013) |
| بيانات النشر: | Karger Publishers, 2013. |
| سنة النشر: | 2013 |
| المجموعة: | LCC:Neurology. Diseases of the nervous system LCC:Geriatrics |
| مصطلحات موضوعية: | CSF biomarkers, Degenerative diseases, Mild cognitive impairment, Subjective cognitive impairment, Cognitive complaints, Depression, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6 |
| الوصف: | Aims: To improve early diagnosis of dementia disease, this study investigates correlates of cognitive complaints and cognitive test performance in patients with subjective (SCI) and mild (MCI) cognitive impairment. Methods: Seventy patients from a memory clinic, aged 45-79, with a score of 2 (n = 23) or 3 (n = 47) on the Global Deterioration Scale, were included. CSF biomarkers [Aβ42, total tau (T-tau) and phosphorylated tau (P-tau)], depressive symptoms, cognitive performance, and complaints were examined. Results: Correlation analysis showed that cognitive complaints increased with decreasing cognitive performance in SCI and decreased with decreasing performance in MCI. Linear regression models revealed that cognitive complaints were associated with depressive symptoms in both groups of patients, while cognitive performance was associated with CSF Aβ42 and P-tau in SCI and with T-tau and P-tau in MCI. Conclusion: These results suggest that depressive symptoms are associated with cognitive complaints, while degenerative changes are associated with objective cognitive decline in high-risk predementia states. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1664-5464 |
| Relation: | http://www.karger.com/Article/FullText/354188; https://doaj.org/toc/1664-5464 |
| DOI: | 10.1159/000354188 |
| URL الوصول: | https://doaj.org/article/c9aa345cf2d143e78ff105c7b3cf70ac |
| رقم الأكسشن: | edsdoj.9aa345cf2d143e78ff105c7b3cf70ac |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16645464 |
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| DOI: | 10.1159/000354188 |