دورية أكاديمية
Arginase II activity regulates cytosolic Ca2+ level in a p32-dependent manner that contributes to Ca2+-dependent vasoconstriction in native low-density lipoprotein-stimulated vascular smooth muscle cells
| العنوان: | Arginase II activity regulates cytosolic Ca2+ level in a p32-dependent manner that contributes to Ca2+-dependent vasoconstriction in native low-density lipoprotein-stimulated vascular smooth muscle cells |
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| المؤلفون: | Bon-hyeock Koo, Dongeui Hong, Hyeon Don Hong, Hyun Kyo Lim, Kwang Lae Hoe, Moo-Ho Won, Young Myeong Kim, Dan E. Berkowitz, Sungwoo Ryoo |
| المصدر: | Experimental and Molecular Medicine, Vol 51, Iss 6, Pp 1-12 (2019) |
| بيانات النشر: | Nature Publishing Group, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Medicine LCC:Biochemistry |
| مصطلحات موضوعية: | Medicine, Biochemistry, QD415-436 |
| الوصف: | Vascular disease: Controlling arterial constriction Researchers have illuminated how a protein, arginase II (ArgII), is involved in development of vascular diseases such as atherosclerosis, or narrowing of the arteries by plaque deposits. Blood vessel diameter is regulated by layers of muscle; the balance between constriction and relaxation is critical for blood flow and vascular health. Increased ArgII is known to be a factor in arterial disease; however, the details of regulation, and how they relate to plaque deposition, remain poorly understood. Sungwoo Ryoo at Kangwon National University, Chuncheon, South Korea and co-workers investigated how ArgII levels affect arterial constriction and relaxation in mice. Decreasing ArgII restored the muscle cells’ contraction response by preventing excessive calcium accumulation in the cellular powerhouse, mitochondria. These results may aid in developing treatments for one of the leading causes of death worldwide. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1226-3613 2092-6413 |
| Relation: | https://doaj.org/toc/1226-3613; https://doaj.org/toc/2092-6413 |
| DOI: | 10.1038/s12276-019-0262-y |
| URL الوصول: | https://doaj.org/article/9abe9aa87a9c496e8d460058ef7359bc |
| رقم الأكسشن: | edsdoj.9abe9aa87a9c496e8d460058ef7359bc |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 12263613 20926413 |
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| DOI: | 10.1038/s12276-019-0262-y |