دورية أكاديمية
Localized disruption of redox homeostasis boosting ferroptosis of tumor by hydrogel delivery system
العنوان: | Localized disruption of redox homeostasis boosting ferroptosis of tumor by hydrogel delivery system |
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المؤلفون: | Xiaomin Su, Yongbin Cao, Yao Liu, Boshu Ouyang, Bo Ning, Yang Wang, Huishu Guo, Zhiqing Pang, Shun Shen |
المصدر: | Materials Today Bio, Vol 12, Iss , Pp 100154- (2021) |
بيانات النشر: | Elsevier, 2021. |
سنة النشر: | 2021 |
المجموعة: | LCC:Medicine (General) LCC:Biology (General) |
مصطلحات موضوعية: | Ferroptosis, Redox homeostasis, Glutathione peroxidase, Alkyl radicals, Hydrogel, Medicine (General), R5-920, Biology (General), QH301-705.5 |
الوصف: | Ferroptosis has received ever-increasing attention due to its unparalleled mechanism in eliminating resistant tumor cells. Nevertheless, the accumulation of toxic lipid peroxides (LPOs) at the tumor site is limited by the level of lipid oxidation. Herein, by leveraging versatile sodium alginate (ALG) hydrogel, a localized ferroptosis trigger consisting of gambogic acid (GA), 2,2′-azobis [2-(2-imidazolin-2-yl) propane] dihydrochloride (AIPH), and Ink (a photothermal agent), was constructed via simple intratumor injection. Upon 1064 nm laser irradiation, the stored AIPH rapidly decomposed into alkyl radicals (R•), which aggravated LPOs in tumor cells. Meanwhile, GA could inhibit heat shock protein 90 (HSP90) to reduce the heat resistance of tumor cells, and forcefully consume glutathione (GSH) to weaken the antioxidant capacity of cells. Systematic in vitro and in vivo experiments have demonstrated that synchronous consumption of GSH and increased reactive oxygen species (ROS) facilitated reduced expression of glutathione peroxidase 4 (GPX4), which further contributed to disruption of intracellular redox homeostasis and ultimately boosted ferroptosis. This all-in-one strategy has a highly effective tumor suppression effect by depleting and generating fatal active compounds at tumor sites, which would pave a new route for the controllable, accurate, and coordinated tumor treatments. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 2590-0064 |
Relation: | http://www.sciencedirect.com/science/article/pii/S2590006421000624; https://doaj.org/toc/2590-0064 |
DOI: | 10.1016/j.mtbio.2021.100154 |
URL الوصول: | https://doaj.org/article/9ae40d38ebf54bc38a49be32b9852376 |
رقم الأكسشن: | edsdoj.9ae40d38ebf54bc38a49be32b9852376 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 25900064 |
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DOI: | 10.1016/j.mtbio.2021.100154 |