دورية أكاديمية
The role of STriatal-Enriched protein tyrosine Phosphastase (STEP) in cognition
| العنوان: | The role of STriatal-Enriched protein tyrosine Phosphastase (STEP) in cognition |
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| المؤلفون: | Christopher James Fitzpatrick, Paul J Lombroso |
| المصدر: | Frontiers in Neuroanatomy, Vol 5 (2011) |
| بيانات النشر: | Frontiers Media S.A., 2011. |
| سنة النشر: | 2011 |
| المجموعة: | LCC:Neurosciences. Biological psychiatry. Neuropsychiatry LCC:Human anatomy |
| مصطلحات موضوعية: | Cognition, Fragile X Syndrome, Schizophrenia, Alzheimer's disease, Huntington's disease, excitotoxicity, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Human anatomy, QM1-695 |
| الوصف: | STriatal-Enriched protein tyrosine Phosphatase (STEP) has recently been implicated in several neuropsychiatric disorders with significant cognitive impairments, including Alzheimer’s disease, schizophrenia, and fragile X syndrome. A model has emerged by which STEP normally opposes the development of synaptic strengthening and that disruption in STEP activity leads to aberrant synaptic function. We review the mechanisms by which STEP contributes to the etiology of these and other neuropsychiatric disorders. These findings suggest that disruptions in STEP activity may be a common mechanism for cognitive impairments in diverse illnesses. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1662-5129 |
| Relation: | http://journal.frontiersin.org/Journal/10.3389/fnana.2011.00047/full; https://doaj.org/toc/1662-5129 |
| DOI: | 10.3389/fnana.2011.00047 |
| URL الوصول: | https://doaj.org/article/9b198e81e3b44fefa4da2195c0ecf841 |
| رقم الأكسشن: | edsdoj.9b198e81e3b44fefa4da2195c0ecf841 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16625129 |
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| DOI: | 10.3389/fnana.2011.00047 |