دورية أكاديمية
Mechanisms Underlying Sex Differences in Temporomandibular Disorders and Their Comorbidity with Migraine
| العنوان: | Mechanisms Underlying Sex Differences in Temporomandibular Disorders and Their Comorbidity with Migraine |
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| المؤلفون: | Adnan Khan, Sufang Liu, Feng Tao |
| المصدر: | Brain Sciences, Vol 14, Iss 7, p 707 (2024) |
| بيانات النشر: | MDPI AG, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| مصطلحات موضوعية: | overlapping orofacial pain, temporomandibular disorders, sex differences, migraine, comorbidity, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| الوصف: | Sexual dimorphism in temporomandibular disorders (TMDs) and their comorbidity with migraine are important phenomena observed in clinics. TMDs are the most prevalent orofacial pain conditions with jaw joint and masseter muscle dysfunction. Migraine is the predominant headache commonly associated with TMDs. Women much more often suffer from this orofacial pain than men. However, currently, there is no gender-specific therapy for such pain conditions. Understanding the pathophysiological mechanisms behind sex differences in TMDs as well as their comorbidity with migraines is essential for developing novel approaches for gender-specific treatment of TMDs and related orofacial pain comorbidity. In this review, we summarize recent research progress regarding sex differences in TMDs, focusing on the underlying mechanisms including craniofacial anatomy, hormonal regulation, and roles of opioids, transient receptor potential channels, and endocannabinoid systems. We also discuss the mechanisms of comorbid TMDs and migraine. The information covered in this review will provide mechanistic insights into sex differences in TMDs and their comorbidity with migraine, which could aid in developing effective treatment strategies for the overlapping orofacial pain condition. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 14070707 2076-3425 |
| Relation: | https://www.mdpi.com/2076-3425/14/7/707; https://doaj.org/toc/2076-3425 |
| DOI: | 10.3390/brainsci14070707 |
| URL الوصول: | https://doaj.org/article/9b1c72a1a1564cc0ab83794827ddd5e6 |
| رقم الأكسشن: | edsdoj.9b1c72a1a1564cc0ab83794827ddd5e6 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14070707 20763425 |
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| DOI: | 10.3390/brainsci14070707 |