دورية أكاديمية
Longitudinal changes in IgG levels among COVID-19 recovered patients: A prospective cohort study.
العنوان: | Longitudinal changes in IgG levels among COVID-19 recovered patients: A prospective cohort study. |
---|---|
المؤلفون: | Ashraf Hassan Alzaabi, Luai A Ahmed, Abdulla E Rabooy, Ali Al Zaabi, Mohammed Alkaabi, Falah AlMahmoud, Mai Farouk Hamed, Khalid Omar Bashaeb, Abdul Rahim Bakhsh, Suha Adil, Nadeen Elmajed, Ahmed Nigm Abousalha, Ahmad Kanaan Uwaydah, Khulood Al Mazrouei |
المصدر: | PLoS ONE, Vol 16, Iss 6, p e0251159 (2021) |
بيانات النشر: | Public Library of Science (PLoS), 2021. |
سنة النشر: | 2021 |
المجموعة: | LCC:Medicine LCC:Science |
مصطلحات موضوعية: | Medicine, Science |
الوصف: | ObjectivesTo quantify SARS-CoV2 IgG antibody titers over time and assess the longevity of the immune response in a multi-ethnic population setting.SettingThis prospective study was conducted in a tertiary hospital in Abu Dhabi city, UAE, among COVID-19 confirmed patients. The virus-specific IgG were measured quantitatively in serum samples from the patients during three visits over a period of 6 months. Serum IgG levels ≥15 AU/ml was used to define a positive response.Participants113 patients were analyzed at first visit, with a mean (SD) age of participants of 45.9 (11.8) years 87.5% of the patients were men. 63 and 27 participants had data available for visits 2 and 3, respectively.Primary outcomeChange in SARS-CoV2 IgG antibody titers over the visits.ResultsNo mortality or re-infection were reported. 69% of the patients developed positive IgG response within the first month after the onset of symptoms. The levels of IgG showed a consistent increase during the first three months with a peak level during the third month. Increasing trend in the levels of IgG were observed in 82.5%, 55.6% and 70.4% of patients between visit 1 to visit 2, visit 2 to visit 3, and from visit 1 to visit 3, respectively. Furthermore, about 64.3% of the patients showed sustained increase in IgG response for more than 120 days.ConclusionsOur study indicates a sustained and prolonged positive immune response in COVID-19 recovered patients. The consistent rise in antibody and positive levels of IgG titers within the first 5 months suggest that immunization is possible, and the chances of reinfection minimal. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1932-6203 |
Relation: | https://doaj.org/toc/1932-6203 |
DOI: | 10.1371/journal.pone.0251159 |
URL الوصول: | https://doaj.org/article/c9b508de268f4dc29cb9b54e8a740bf6 |
رقم الأكسشن: | edsdoj.9b508de268f4dc29cb9b54e8a740bf6 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 19326203 |
---|---|
DOI: | 10.1371/journal.pone.0251159 |