دورية أكاديمية
أعرض في EDS

Longitudinal changes in IgG levels among COVID-19 recovered patients: A prospective cohort study.

التفاصيل البيبلوغرافية
العنوان: Longitudinal changes in IgG levels among COVID-19 recovered patients: A prospective cohort study.
المؤلفون: Ashraf Hassan Alzaabi, Luai A Ahmed, Abdulla E Rabooy, Ali Al Zaabi, Mohammed Alkaabi, Falah AlMahmoud, Mai Farouk Hamed, Khalid Omar Bashaeb, Abdul Rahim Bakhsh, Suha Adil, Nadeen Elmajed, Ahmed Nigm Abousalha, Ahmad Kanaan Uwaydah, Khulood Al Mazrouei
المصدر: PLoS ONE, Vol 16, Iss 6, p e0251159 (2021)
بيانات النشر: Public Library of Science (PLoS), 2021.
سنة النشر: 2021
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: ObjectivesTo quantify SARS-CoV2 IgG antibody titers over time and assess the longevity of the immune response in a multi-ethnic population setting.SettingThis prospective study was conducted in a tertiary hospital in Abu Dhabi city, UAE, among COVID-19 confirmed patients. The virus-specific IgG were measured quantitatively in serum samples from the patients during three visits over a period of 6 months. Serum IgG levels ≥15 AU/ml was used to define a positive response.Participants113 patients were analyzed at first visit, with a mean (SD) age of participants of 45.9 (11.8) years 87.5% of the patients were men. 63 and 27 participants had data available for visits 2 and 3, respectively.Primary outcomeChange in SARS-CoV2 IgG antibody titers over the visits.ResultsNo mortality or re-infection were reported. 69% of the patients developed positive IgG response within the first month after the onset of symptoms. The levels of IgG showed a consistent increase during the first three months with a peak level during the third month. Increasing trend in the levels of IgG were observed in 82.5%, 55.6% and 70.4% of patients between visit 1 to visit 2, visit 2 to visit 3, and from visit 1 to visit 3, respectively. Furthermore, about 64.3% of the patients showed sustained increase in IgG response for more than 120 days.ConclusionsOur study indicates a sustained and prolonged positive immune response in COVID-19 recovered patients. The consistent rise in antibody and positive levels of IgG titers within the first 5 months suggest that immunization is possible, and the chances of reinfection minimal.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0251159
URL الوصول: https://doaj.org/article/c9b508de268f4dc29cb9b54e8a740bf6
رقم الأكسشن: edsdoj.9b508de268f4dc29cb9b54e8a740bf6
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0251159