دورية أكاديمية
Exosomal Micro-RNAs as Intercellular Communicators in Idiopathic Pulmonary Fibrosis
| العنوان: | Exosomal Micro-RNAs as Intercellular Communicators in Idiopathic Pulmonary Fibrosis |
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| المؤلفون: | María Cristina Negrete-García, Javier de Jesús Ramos-Abundis, Noé Alvarado-Vasquez, Eduardo Montes-Martínez, Martha Montaño, Carlos Ramos, Bettina Sommer |
| المصدر: | International Journal of Molecular Sciences, Vol 23, Iss 19, p 11047 (2022) |
| بيانات النشر: | MDPI AG, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | exosomes, extracellular vesicles, miRNA, exosomal miRNAs, idiopathic pulmonary fibrosis, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Communication between neighboring or distant cells is made through a complex network that includes extracellular vesicles (EVs). Exosomes, which are a subgroup of EVs, are released from most cell types and have been found in biological fluids such as urine, plasma, and airway secretions like bronchoalveolar lavage (BAL), nasal lavage, saliva, and sputum. Mainly, the cargo exosomes are enriched with mRNAs and microRNAs (miRNAs), which can be transferred to a recipient cell consequently modifying and redirecting its biological function. The effects of miRNAs derive from their role as gene expression regulators by repressing or degrading their target mRNAs. Nowadays, various types of research are focused on evaluating the potential of exosomal miRNAs as biomarkers for the prognosis and diagnosis of different pathologies. Nevertheless, there are few reports on their role in the pathophysiology of idiopathic pulmonary fibrosis (IPF), a chronic lung disease characterized by progressive lung scarring with no cure. In this review, we focus on the role and effect of exosomal miRNAs as intercellular communicators in the onset and progression of IPF, as well as discussing their potential utility as therapeutic agents for the treatment of this disease. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 23191104 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/23/19/11047; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms231911047 |
| URL الوصول: | https://doaj.org/article/9b6937d896584713904634708768a1b7 |
| رقم الأكسشن: | edsdoj.9b6937d896584713904634708768a1b7 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23191104 14220067 16616596 |
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| DOI: | 10.3390/ijms231911047 |