دورية أكاديمية
Wound healing by topical application of Momordica charantia L. formulations on mice
| العنوان: | Wound healing by topical application of Momordica charantia L. formulations on mice |
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| المؤلفون: | William Antonio Sagástegui-Guarniz, Carmen R. Silva-Correa, Víctor E. Villarreal-La Torre, María V. González-Blas, Walter O. Sagástegui-Guarniz, Abhel A. Calderón-Peña, Cinthya L. Aspajo-Villalaz, José L. Cruzado-Razco, Julio Hilario-Vargas |
| المصدر: | Veterinary World, Vol 14, Iss 10, Pp 2699-2704 (2021) |
| بيانات النشر: | Veterinary World, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Animal culture LCC:Veterinary medicine |
| مصطلحات موضوعية: | histology, momordica charantia, skin, topical administration, wound healing, Animal culture, SF1-1100, Veterinary medicine, SF600-1100 |
| الوصف: | Background and Aim: Momordica charantia is mainly characterized by its antimicrobial and antioxidant properties. The current study aimed to evaluate the healing activity of gel and cream formulations based on M. charantia on induced wounds in mice. Materials and Methods: Acetonic extract of M. charantia was prepared and incorporated into gel and cream formulations. Mus musculus Balb/c (n=30) with induced injury were distributed into five groups: Group I (control – day 7), Group II (control – day 14), Group III (1% gel – day 7), and Group IV (1% gel – day 14) to which 1% M. charantia gel was dermally applied daily for 7 and 14 days, respectively, Group V (1% cream – day 7) and Group VI (1% cream – day 14) to which of M. charantia 1% cream were dermally applied daily for 7 and 14 days, respectively. Time of wound closure was determined during the experimentation; rats were euthanized with sodium pentobarbital 60 mg/kg/pc v.ip. for obtaining skin samples for histopathological analysis. Results: Groups IV and VI showed a higher percentage of wound closure on day 14, and in histopathological analysis, effect was greater in Group VI with the presence of fibroblasts and abundant collagen and elastic fibers. Conclusion: M. charantia gel and cream showed wound healing activity on induced wounded mice; the most effective treatment was M. charantia 1% cream formulation. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0972-8988 2231-0916 |
| Relation: | http://www.veterinaryworld.org/Vol.14/October-2021/17.pdf; https://doaj.org/toc/0972-8988; https://doaj.org/toc/2231-0916 |
| DOI: | 10.14202/vetworld.2021.2699-2704 |
| URL الوصول: | https://doaj.org/article/9b83b211bc624b4aa238b1801c712ad4 |
| رقم الأكسشن: | edsdoj.9b83b211bc624b4aa238b1801c712ad4 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 09728988 22310916 |
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| DOI: | 10.14202/vetworld.2021.2699-2704 |