دورية أكاديمية
A rare case of a toddler with unilateral cryptorchidism‐related cranial suspensory ligament remnant
| العنوان: | A rare case of a toddler with unilateral cryptorchidism‐related cranial suspensory ligament remnant |
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| المؤلفون: | Hideaki Nakajima, Kazuto Suda, Atsushi Arakawa, Toshihiro Yanai |
| المصدر: | Clinical Case Reports, Vol 11, Iss 5, Pp n/a-n/a (2023) |
| بيانات النشر: | Wiley, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine LCC:Medicine (General) |
| مصطلحات موضوعية: | androgen receptor, cranial suspensory ligament, cryptorchidism, gubernaculum, testicular descent, Medicine, Medicine (General), R5-920 |
| الوصف: | Key clinical message Several animal experiment studies have shown that insufficient testicular descent to the scrotum can be caused by persistence of cranial suspensory ligament (CSL). We report a case of right cryptorchidism in a male toddler surgically treated with an orchidopexy possibly associated with CSL persistence based on intraoperative and pathological findings. This case would be a precious source to further investigate the etiopathogenesis of cryptorchidism. Abstract The CSL anchors embryonic gonads to the dorsal abdominal wall during antenatal mammalian development. Although its persistence appears to cause cryptorchidism in animal models, it has never been proven in humans. A 1‐year‐old boy with right cryptorchidism underwent right orchidopexy. Intraoperatively, a band‐like structure running from the right testis into the retroperitoneum and up to the right side of the liver was noticed and resected. The pathological findings of the specimen showed fibrous connective tissues, smooth muscles, and blood vessels but no tissues suggestive of a testis, a spermatic cord, an epididymis, or liver. Immunohistochemical analysis for an androgen receptor antibody did not detect any signal in the specimen. The right cryptorchidism in this case was possibly caused by CSL persistence, which is the first such human case, to our knowledge. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2050-0904 |
| Relation: | https://doaj.org/toc/2050-0904 |
| DOI: | 10.1002/ccr3.7310 |
| URL الوصول: | https://doaj.org/article/9c4d9934057e4ad9957661e3d1dfb92c |
| رقم الأكسشن: | edsdoj.9c4d9934057e4ad9957661e3d1dfb92c |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20500904 |
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| DOI: | 10.1002/ccr3.7310 |