دورية أكاديمية
Multifunctional Interleukin-24 Resolves Neuroretina Autoimmunity via Diverse Mechanisms
| العنوان: | Multifunctional Interleukin-24 Resolves Neuroretina Autoimmunity via Diverse Mechanisms |
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| المؤلفون: | Xuan Zhang, Cuiping Hu, Yajie Zhong, Dijie Qiao, Wei Chi, Huangxuan Shen, Waipo Chong |
| المصدر: | International Journal of Molecular Sciences, Vol 23, Iss 19, p 11988 (2022) |
| بيانات النشر: | MDPI AG, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | IL-24, T helper cells, RPE cells, autoimmune uveitis, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | IL-24 is a multifunctional cytokine that regulates both immune cells and epithelial cells. Although its elevation is associated with a number of autoimmune diseases, its tolerogenic properties against autoreactive T cells have recently been revealed in an animal model of central nervous system (CNS) autoimmunity by inhibiting the pathogenic Th17 response. To explore the potential of IL-24 as a therapeutic agent in CNS autoimmunity, we induced experimental autoimmune uveitis (EAU) in wildtype mice and intravitreally injected IL-24 into the inflamed eye after disease onset. We found that the progression of ocular inflammation was significantly inhibited in the IL-24-treated eye when compared to the control eye. More importantly, IL-24 treatment suppressed cytokine production from ocular-infiltrating, pathogenic Th1 and Th17 cells. In vitro experiments confirmed that IL-24 suppressed both Th1 and Th17 differentiation by regulating their master transcription factors T-bet and RORγt, respectively. In addition, we found that intravitreal injection of IL-24 suppressed the production of proinflammatory cytokines and chemokines from the retinas of the EAU-inflamed eyes. This observation appears to be applicable in humans, as IL-24 similarly inhibits human retinal pigment epithelium cells ARPE-19. In conclusion, we report here that IL-24, as a multifunctional cytokine, is capable of resolving ocular inflammation in EAU mice by targeting both uveitogenic T cells and RPE cells. This study sheds new light on IL-24 as a potential therapeutic candidate for autoimmune uveitis. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 23191198 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/23/19/11988; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms231911988 |
| URL الوصول: | https://doaj.org/article/9c561cdd1d00406ab3d1d78e86b53a26 |
| رقم الأكسشن: | edsdoj.9c561cdd1d00406ab3d1d78e86b53a26 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23191198 14220067 16616596 |
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| DOI: | 10.3390/ijms231911988 |