دورية أكاديمية
CRISPR/Cas9 gene editing: a new approach for overcoming drug resistance in cancer
العنوان: | CRISPR/Cas9 gene editing: a new approach for overcoming drug resistance in cancer |
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المؤلفون: | Mostafa Vaghari-Tabari, Parisa Hassanpour, Fatemeh Sadeghsoltani, Faezeh Malakoti, Forough Alemi, Durdi Qujeq, Zatollah Asemi, Bahman Yousefi |
المصدر: | Cellular & Molecular Biology Letters, Vol 27, Iss 1, Pp 1-29 (2022) |
بيانات النشر: | BMC, 2022. |
سنة النشر: | 2022 |
المجموعة: | LCC:Cytology |
مصطلحات موضوعية: | CRISPR/Cas9, Gene editing, Chemoresistance, Malignancy, Cancer treatment, Cytology, QH573-671 |
الوصف: | Abstract The CRISPR/Cas9 system is an RNA-based adaptive immune system in bacteria and archaea. Various studies have shown that it is possible to target a wide range of human genes and treat some human diseases, including cancers, by the CRISPR/Cas9 system. In fact, CRISPR/Cas9 gene editing is one of the most efficient genome manipulation techniques. Studies have shown that CRISPR/Cas9 technology, in addition to having the potential to be used as a new therapeutic approach in the treatment of cancers, can also be used to enhance the effectiveness of existing treatments. Undoubtedly, the issue of drug resistance is one of the main obstacles in the treatment of cancers. Cancer cells resist anticancer drugs by a variety of mechanisms, such as enhancing anticancer drugs efflux, enhancing DNA repair, enhancing stemness, and attenuating apoptosis. Mutations in some proteins of different cellular signaling pathways are associated with these events and drug resistance. Recent studies have shown that the CRISPR/Cas9 technique can be used to target important genes involved in these mechanisms, thereby increasing the effectiveness of anticancer drugs. In this review article, studies related to the applications of this technique in overcoming drug resistance in cancer cells will be reviewed. In addition, we will give a brief overview of the limitations of the CRISP/Cas9 gene-editing technique. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1425-8153 1689-1392 |
Relation: | https://doaj.org/toc/1425-8153; https://doaj.org/toc/1689-1392 |
DOI: | 10.1186/s11658-022-00348-2 |
URL الوصول: | https://doaj.org/article/ae9c7458709c4d66a2da901077deec4b |
رقم الأكسشن: | edsdoj.9c7458709c4d66a2da901077deec4b |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 14258153 16891392 |
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DOI: | 10.1186/s11658-022-00348-2 |