دورية أكاديمية
Integrated analysis of the Plasmodium species transcriptome
| العنوان: | Integrated analysis of the Plasmodium species transcriptome |
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| المؤلفون: | Regina Hoo, Lei Zhu, Anburaj Amaladoss, Sachel Mok, Onguma Natalang, Stacey A. Lapp, Guangan Hu, Kingsley Liew, Mary R. Galinski, Zbynek Bozdech, Peter R. Preiser |
| المصدر: | EBioMedicine, Vol 7, Iss C, Pp 255-266 (2016) |
| بيانات النشر: | Elsevier, 2016. |
| سنة النشر: | 2016 |
| المجموعة: | LCC:Medicine LCC:Medicine (General) |
| مصطلحات موضوعية: | Comparative transcriptomics, Plasmodium species, Evolution, Microarray, Transcriptome, Drug targets, Medicine, Medicine (General), R5-920 |
| الوصف: | The genome sequence available for different Plasmodium species is a valuable resource for understanding malaria parasite biology. However, comparative genomics on its own cannot fully explain all the species-specific differences which suggests that other genomic aspects such as regulation of gene expression play an important role in defining species-specific characteristics. Here, we developed a comprehensive approach to measure transcriptional changes of the evolutionary conserved syntenic orthologs during the intraerythrocytic developmental cycle across six Plasmodium species. We show significant transcriptional constraint at the mid-developmental stage of Plasmodium species while the earliest stages of parasite development display the greatest transcriptional variation associated with critical functional processes. Modeling of the evolutionary relationship based on changes in transcriptional profile reveal a phylogeny pattern of the Plasmodium species that strictly follows its mammalian hosts. In addition, the work shows that transcriptional conserved orthologs represent potential future targets for anti-malaria intervention as they would be expected to carry out key essential functions within the parasites. This work provides an integrated analysis of orthologous transcriptome, which aims to provide insights into the Plasmodium evolution thereby establishing a framework to explore complex pathways and drug discovery in Plasmodium species with broad host range. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2352-3964 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2352396416301475; https://doaj.org/toc/2352-3964 |
| DOI: | 10.1016/j.ebiom.2016.04.011 |
| URL الوصول: | https://doaj.org/article/9c858bda6e8742c98a19aa3cf7a84a41 |
| رقم الأكسشن: | edsdoj.9c858bda6e8742c98a19aa3cf7a84a41 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 23523964 |
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| DOI: | 10.1016/j.ebiom.2016.04.011 |