دورية أكاديمية
Modular polymer platform as a novel approach to head and neck cancer therapy
العنوان: | Modular polymer platform as a novel approach to head and neck cancer therapy |
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المؤلفون: | Yazeed Alhiyari, Jundong Shao, Albert Y. Han, Amanda Miller, Jeffrey F. Krane, Marie Luff, Milica Momcilovic, David Shackelford, Zhen Gu, Maie A. St. John |
المصدر: | Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022) |
بيانات النشر: | Nature Portfolio, 2022. |
سنة النشر: | 2022 |
المجموعة: | LCC:Medicine LCC:Science |
مصطلحات موضوعية: | Medicine, Science |
الوصف: | Abstract Head and neck cancer is the sixth most common cancer in the world, with more than 300,000 deaths attributed to the disease annually. Aggressive surgical resection often with adjuvant chemoradiation is the cornerstone of treatment. However, the necessary chemoradiation treatment can result in collateral damage to adjacent vital structures causing a profound impact on quality of life. Here, we present a novel polymer of poly(lactic-co-glycolic) acid and polyvinyl alcohol that can serve as a versatile multidrug delivery platform as well as for detection on cross-sectional imaging while functioning as a fiduciary marker for postoperative radiotherapy and radiotherapeutic dosing. In a mouse xenograft model, the dual-layered polymer composed of calcium carbonate/thymoquinone was used for both polymer localization and narrow-field infusion of a natural therapeutic compound. A similar approach can be applied in the treatment of head and neck cancer patients, where immunotherapy and traditional chemotherapy can be delivered simultaneously with independent release kinetics. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 2045-2322 |
Relation: | https://doaj.org/toc/2045-2322 |
DOI: | 10.1038/s41598-022-07324-y |
URL الوصول: | https://doaj.org/article/9d07aca2b824450bb85a66858d5c92ec |
رقم الأكسشن: | edsdoj.9d07aca2b824450bb85a66858d5c92ec |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 20452322 |
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DOI: | 10.1038/s41598-022-07324-y |