دورية أكاديمية
Intra-articular injection of ascorbic acid enhances microfracture-mediated cartilage repair
| العنوان: | Intra-articular injection of ascorbic acid enhances microfracture-mediated cartilage repair |
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| المؤلفون: | Zhian Chen, Sihe Zhang, Peiya Duan, Zhengbo Yin, Shuangbin Dong, Rongqing Pang, Hongbo Tan |
| المصدر: | Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024) |
| بيانات النشر: | Nature Portfolio, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Intra-articular injection, Ascorbic acid, Microfractures, Cartilage repair, Medicine, Science |
| الوصف: | Abstract Previous studies have confirmed that ascorbic acid (AA) can promote cartilage repair and improve cartilage differentiation in bone marrow mesenchymal stem cells. However, the use of microfracture (MFX) combined with AA to repair cartilage damage has not been studied. This study established a rabbit animal model and treated cartilage injury with different concentrations of AA combined with MFX. Macroscopic observations, histological analysis, immunohistochemical analysis and reverse transcription quantitative polymerase chain reaction analysis of TGF-β, AKT/Nrf2, and VEGF mRNA expression were performed. The results showed that intra-articular injection of AA had a positive effect on cartilage repair mediated by microfractures. Moreover, 10 mg/ml AA was the most effective at promoting cartilage repair mediated by microfractures. Intra-articular injection of AA promoted the synthesis of type II collagen and the formation of glycosaminoglycans by downregulating the mRNA expression of TGF-β and VEGF. In summary, this study confirmed that AA could promote cartilage repair after MFX surgery. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-024-54514-x |
| URL الوصول: | https://doaj.org/article/9d5184d3b596447dac150a68431e82a5 |
| رقم الأكسشن: | edsdoj.9d5184d3b596447dac150a68431e82a5 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-024-54514-x |