دورية أكاديمية
Fumarate exerted an antihypertensive effect and reduced kidney injury molecule (KIM)-1 expression in deoxycorticosterone acetate-salt hypertension
| العنوان: | Fumarate exerted an antihypertensive effect and reduced kidney injury molecule (KIM)-1 expression in deoxycorticosterone acetate-salt hypertension |
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| المؤلفون: | Osaze Edosuyi, Myung Choi, Ighodaro Igbe, Adebayo Oyekan |
| المصدر: | Clinical and Experimental Hypertension, Vol 43, Iss 6, Pp 555-564 (2021) |
| بيانات النشر: | Taylor & Francis Group, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Diseases of the circulatory (Cardiovascular) system |
| مصطلحات موضوعية: | fumarate, hypertension, l-arginine metabolism, redox state, tricarboxylic acid cycle, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| الوصف: | Background: The tricarboxylic (TCA) acid cycle provides the energy needed for regulatory functions in the cardio-renal system. Recently, a genetic defect in the TCA cycle enzyme, fumarase hydratase, altered L-arginine metabolism and exacerbated hypertension in salt-sensitive rats. This study evaluated the effect of fumarate and its possible link to L-arginine metabolism in deoxycorticosterone (DOCA)-salt hypertension, a non-genetic model of hypertension.Method: Hypertension was induced with DOCA (25 mg/kg s.c, twice weekly) + 1% NaCL in uninephrectomised rats placed on fumarate (1 g/L, ad libitum). Blood pressure was measured in conscious rats via carotid cannulation. Biochemical and western blot analyses were carried out on kidney fractions.Results: Fumarate reduced mean blood pressure (198 ± 5 vs 167 ± 7 mmHg, p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1064-1963 1525-6006 10641963 |
| Relation: | https://doaj.org/toc/1064-1963; https://doaj.org/toc/1525-6006 |
| DOI: | 10.1080/10641963.2021.1916943 |
| URL الوصول: | https://doaj.org/article/9d6df4c2b81046aba984ff14115eb24b |
| رقم الأكسشن: | edsdoj.9d6df4c2b81046aba984ff14115eb24b |
| قاعدة البيانات: | Directory of Open Access Journals |
PDF full text from Publisher | تدمد: | 10641963 15256006 |
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| DOI: | 10.1080/10641963.2021.1916943 |