دورية أكاديمية
Functional modulation of gut microbiota in diabetic rats following dietary intervention with pistachio nuts (Pistacia vera L.)
| العنوان: | Functional modulation of gut microbiota in diabetic rats following dietary intervention with pistachio nuts (Pistacia vera L.) |
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| المؤلفون: | Amalia E. Yanni, Gregoria Mitropoulou, Ioanna Prapa, Georgios Agrogiannis, Nikolaos Kostomitsopoulos, Eugenia Bezirtzoglou, Yiannis Kourkoutas, Vaios T. Karathanos |
| المصدر: | Metabolism Open, Vol 7, Iss , Pp 100040- (2020) |
| بيانات النشر: | Elsevier, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Physiology LCC:Biochemistry |
| مصطلحات موضوعية: | Type 1 diabetes, Streptozotocin-induced diabetes, Pistachio nuts, Gut microbiota, Bifidobacteria, Lactobacilli, Physiology, QP1-981, Biochemistry, QD415-436 |
| الوصف: | Background: Gut microbiota holds a key-role in numerous biological functions and has emerged as a driving force for the development of diabetes. Diet contributes to gut microbiota diversity and functionality providing a tool for the prevention and management of the disease. The study aimed to investigate the effect of a dietary intervention with pistachio nuts, a rich source of monounsaturated fatty acids, dietary fibers and phytochemicals on gut microbiota composition in the rat model of Type 1 Diabetes. Methods: Male Wistar rats were randomly assigned into four groups: healthy animals which received control diet (CD) or pistachio diet (PD), and diabetic animals which received control diet (DCD) or pistachio diet (DPD) for 4 weeks. Plasma biochemical parameters were determined and histological examination of liver and pancreas was performed at the end of the dietary intervention. Adherent intestinal microbiota populations in jejunum, ileum, caecum and colon were analyzed. Fecal microbiota populations at the beginning and the end of the study were determined by microbiological analysis and 16S rRNA sequencing. Results: Diabetic animals of both groups exhibited high plasma glucose and low insulin concentrations, as well as characteristic pancreatic lesions. Pistachio supplementation significantly increased lactobacilli and bifidobacteria populations in jejunum, ileum and caecum (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2589-9368 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2589936820300207; https://doaj.org/toc/2589-9368 |
| DOI: | 10.1016/j.metop.2020.100040 |
| URL الوصول: | https://doaj.org/article/ed9d8797b15642338a3c0e05a2ce4f1f |
| رقم الأكسشن: | edsdoj.9d8797b15642338a3c0e05a2ce4f1f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 25899368 |
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| DOI: | 10.1016/j.metop.2020.100040 |