دورية أكاديمية
Chansu improves the respiratory function of severe COVID-19 patients
| العنوان: | Chansu improves the respiratory function of severe COVID-19 patients |
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| المؤلفون: | Fen Hu, Jiao Chen, Hao Chen, Jin Zhu, Chen Wang, Haibin Ni, Jianming Cheng, Xingxing Hu, Peng Cao |
| المصدر: | Pharmacological Research - Modern Chinese Medicine, Vol 1, Iss , Pp 100007- (2021) |
| بيانات النشر: | Elsevier, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Other systems of medicine LCC:Therapeutics. Pharmacology |
| مصطلحات موضوعية: | Chansu, COVID-19, Respiratory function, SARS-CoV-2, ATP1A1, Other systems of medicine, RZ201-999, Therapeutics. Pharmacology, RM1-950 |
| الوصف: | Targeted therapeutics for SARS-CoV-2 virus caused COVID-19 are in urgent need. Chansu has been reported to have broad-spectrum antiviral effects and widely used in Southeast Asian countries. This study aims to assess the efficacy of Chansu injection in treating patients with severe COVID-19. A randomized preliminary clinical trial was conducted and eligible patients were allocated to receive general treatment plus Chansu injection or only general treatment as control for 7 days. The primary outcomes of the oxygenation index PaO2/FiO2 and ROX, secondary outcomes of white blood cell count, respiratory support step-down time (RSST), safety indicators, etc were monitored. After 7 days of treatment, the oxygenation index was improved in 95.2% patients in the treatment group compared with 68.4% in the control group. The PaO2/FiO2 and ROX indices in the treatment group (mean, 226.27±67.35 and 14.01±3.99 respectively) were significantly higher than the control group (mean, 143.23±51.29 and 9.64±5.54 respectively). The RSST was 1 day shorter in the treatment group. Multivariate regression analysis suggested that Chansu injection contributed the most to the outcome of PaO2/FiO2. No obvious adverse effects were observed. The preliminary data showed that Chansu injection had apparent efficacy in improving the respiratory function of patients with severe COVID-19. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2667-1425 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2667142521000063; https://doaj.org/toc/2667-1425 |
| DOI: | 10.1016/j.prmcm.2021.100007 |
| URL الوصول: | https://doaj.org/article/ae9d9861b14b46e0be01856026877300 |
| رقم الأكسشن: | edsdoj.9d9861b14b46e0be01856026877300 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 26671425 |
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| DOI: | 10.1016/j.prmcm.2021.100007 |