دورية أكاديمية
أعرض في EDS

Dihydrocoumarin, an HDAC Inhibitor, Increases DNA Damage Sensitivity by Inhibiting Rad52

التفاصيل البيبلوغرافية
العنوان: Dihydrocoumarin, an HDAC Inhibitor, Increases DNA Damage Sensitivity by Inhibiting Rad52
المؤلفون: Chin-Chuan Chen, Ju-Sui Huang, Tong-Hong Wang, Chen-Hsin Kuo, Chia-Jen Wang, Shu-Huei Wang, Yann-Lii Leu
المصدر: International Journal of Molecular Sciences, Vol 18, Iss 12, p 2655 (2017)
بيانات النشر: MDPI AG, 2017.
سنة النشر: 2017
المجموعة: LCC:Biology (General)
LCC:Chemistry
مصطلحات موضوعية: yeast, DSB, DHC, DNA damage sensitivity, homologous recombination, Rad52, Biology (General), QH301-705.5, Chemistry, QD1-999
الوصف: Effective DNA repair enables cancer cells to survive DNA damage induced by chemotherapeutic or radiotherapeutic treatments. Therefore, inhibiting DNA repair pathways is a promising therapeutic strategy for increasing the efficacy of such treatments. In this study, we found that dihydrocoumarin (DHC), a flavoring agent, causes deficiencies in double-stand break (DSB) repair and prolonged DNA damage checkpoint recovery in yeast. Following DNA damage, Rad52 recombinase was revealed to be inhibited by DHC, which results in deficiencies in DSB repair and prolonged DNA damage checkpoint recovery. The deletion of RPD3, a class I histone deacetylase (HDAC), was found to mimic DHC-induced suppression of Rad52 expression, suggesting that the HDAC inhibitor activity of DHC is critical to DSB repair and DNA damage sensitivity. Overall, our findings delineate the regulatory mechanisms of DHC in DSB repair and suggest that it might potentially be used as an inhibitor of the DNA repair pathway in human cells.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1422-0067
18122655
Relation: https://www.mdpi.com/1422-0067/18/12/2655; https://doaj.org/toc/1422-0067
DOI: 10.3390/ijms18122655
URL الوصول: https://doaj.org/article/9dd1fae61afa4a63a67de65da2cadb6a
رقم الأكسشن: edsdoj.9dd1fae61afa4a63a67de65da2cadb6a
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14220067
18122655
DOI:10.3390/ijms18122655