دورية أكاديمية
Acupuncture modulates the abnormal brainstem activity in migraine without aura patients
| العنوان: | Acupuncture modulates the abnormal brainstem activity in migraine without aura patients |
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| المؤلفون: | Zhengjie Li, Fang Zeng, Tao Yin, Lei Lan, Nikos Makris, Kristen Jorgenson, Taipin Guo, Feng Wu, Yujie Gao, Mingkai Dong, Mailan Liu, Jie Yang, Ying Li, Qiyong Gong, Fanrong Liang, Jian Kong |
| المصدر: | NeuroImage: Clinical, Vol 15, Iss , Pp 367-375 (2017) |
| بيانات النشر: | Elsevier, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Computer applications to medicine. Medical informatics LCC:Neurology. Diseases of the nervous system |
| مصطلحات موضوعية: | Computer applications to medicine. Medical informatics, R858-859.7, Neurology. Diseases of the nervous system, RC346-429 |
| الوصف: | Migraine is a common neurological disease with a high prevalence and unsatisfactory treatment options. The specific pathophysiological mechanisms of migraine remain unclear, which restricts the development of effective treatments for this prevalent disorder. The aims of this study were to 1) compare the spontaneous brain activity differences between Migraine without Aura (MwoA) patients and healthy controls (HCs), using amplitude of low-frequency fluctuations (ALFF) calculation method, and 2) explore how an effective treatment (verum acupuncture) could modulate the ALFF of MwoA patients. One hundred MwoA patients and forty-six matched HCs were recruited. Patients were randomized to four weeks' verum acupuncture, sham acupuncture, and waiting list groups. Patients had resting state BOLD-fMRI scan before and after treatment, while HCs only had resting state BOLD-fMRI scan at baseline. Headache intensity, headache frequency, self-rating anxiety and self-rating depression were used for clinical efficacy evaluation. Compared with HCs, MwoA patients showed increased ALFF in posterior insula and putamen/caudate, and reduced ALFF in rostral ventromedial medulla (RVM)/trigeminocervical complex (TCC). After longitudinal verum acupuncture treatment, the decreased ALFF of the RVM/TCC was normalized in migraine patients. Verum acupuncture and sham acupuncture have different modulation effects on ALFF of RVM/TCC in migraine patients. Our results suggest that impairment of the homeostasis of the trigeminovascular nociceptive pathway is involved in the neural pathophysiology of migraines. Effective treatments, such as verum acupuncture, could help to restore this imbalance. Keywords: Migraine, Amplitude of low-frequency fluctuations, Brainsterm, Trigeminocervical complex, Acupuncture, Resting state fMRI |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2213-1582 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2213158217301183; https://doaj.org/toc/2213-1582 |
| DOI: | 10.1016/j.nicl.2017.05.013 |
| URL الوصول: | https://doaj.org/article/9df45b82e0424f70b7ff6dd3bbc86369 |
| رقم الأكسشن: | edsdoj.9df45b82e0424f70b7ff6dd3bbc86369 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 22131582 |
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| DOI: | 10.1016/j.nicl.2017.05.013 |