دورية أكاديمية
Syndapin bridges the membrane-cytoskeleton divide during furrow extension
العنوان: | Syndapin bridges the membrane-cytoskeleton divide during furrow extension |
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المؤلفون: | Aparna Sherlekar, Richa Rikhy |
المصدر: | Communicative & Integrative Biology, Vol 10, Iss 1 (2017) |
بيانات النشر: | Taylor & Francis Group, 2017. |
سنة النشر: | 2017 |
المجموعة: | LCC:Biology (General) |
مصطلحات موضوعية: | actin, Drosophila, F-BAR, furrow extension, metaphase furrow, plasma membrane tension, syncytium, syndapin, Biology (General), QH301-705.5 |
الوصف: | BAR domain proteins can regulate ‘membrane reservoirs’ that provide surface area and buffer membrane tension. Syndapin is an F-BAR and SH3 domain containing protein involved in cytoskeletal remodelling and endocytosis. The Syndapin F-BAR domain is uniquely versatile compared to others in the family and can bend phospholipid membranes into tubules of various diameters and directly bind actin. The Syndapin SH3 domain can also interact with actin remodelling proteins and modulate cytoskeletal contractility. Pseudocleavage furrow extension in the syncytial division cycles of Drosophila embryos requires the homeostatic control of conserved processes that control plasma membrane tension and actin contractility. We find that Syndapin plays an important role in promoting pseudocleavage furrow extension. We propose a model involving roles for Syndapin in membrane dynamics and direct or indirect effect on the cytoskeleton to explain how it affects pseudocleavage furrow growth, independent of its role in endocytosis. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1942-0889 19420889 |
Relation: | https://doaj.org/toc/1942-0889 |
DOI: | 10.1080/19420889.2016.1255832 |
URL الوصول: | https://doaj.org/article/9e663482881a4095875f35982f6dca47 |
رقم الأكسشن: | edsdoj.9e663482881a4095875f35982f6dca47 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 19420889 |
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DOI: | 10.1080/19420889.2016.1255832 |