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Syndapin bridges the membrane-cytoskeleton divide during furrow extension

التفاصيل البيبلوغرافية
العنوان: Syndapin bridges the membrane-cytoskeleton divide during furrow extension
المؤلفون: Aparna Sherlekar, Richa Rikhy
المصدر: Communicative & Integrative Biology, Vol 10, Iss 1 (2017)
بيانات النشر: Taylor & Francis Group, 2017.
سنة النشر: 2017
المجموعة: LCC:Biology (General)
مصطلحات موضوعية: actin, Drosophila, F-BAR, furrow extension, metaphase furrow, plasma membrane tension, syncytium, syndapin, Biology (General), QH301-705.5
الوصف: BAR domain proteins can regulate ‘membrane reservoirs’ that provide surface area and buffer membrane tension. Syndapin is an F-BAR and SH3 domain containing protein involved in cytoskeletal remodelling and endocytosis. The Syndapin F-BAR domain is uniquely versatile compared to others in the family and can bend phospholipid membranes into tubules of various diameters and directly bind actin. The Syndapin SH3 domain can also interact with actin remodelling proteins and modulate cytoskeletal contractility. Pseudocleavage furrow extension in the syncytial division cycles of Drosophila embryos requires the homeostatic control of conserved processes that control plasma membrane tension and actin contractility. We find that Syndapin plays an important role in promoting pseudocleavage furrow extension. We propose a model involving roles for Syndapin in membrane dynamics and direct or indirect effect on the cytoskeleton to explain how it affects pseudocleavage furrow growth, independent of its role in endocytosis.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1942-0889
19420889
Relation: https://doaj.org/toc/1942-0889
DOI: 10.1080/19420889.2016.1255832
URL الوصول: https://doaj.org/article/9e663482881a4095875f35982f6dca47
رقم الأكسشن: edsdoj.9e663482881a4095875f35982f6dca47
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19420889
DOI:10.1080/19420889.2016.1255832