دورية أكاديمية
20 abnormal metabolites of Stage IV Grade C periodontitis was discovered by CPSI-MS
| العنوان: | 20 abnormal metabolites of Stage IV Grade C periodontitis was discovered by CPSI-MS |
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| المؤلفون: | Li-Jun Wang, Liu Liu, Wei Ju, Wen-Xin Yao, Xi-Hu Yang, Wen-Hao Qian |
| المصدر: | Pathology and Oncology Research, Vol 28 (2022) |
| بيانات النشر: | Frontiers Media S.A., 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens LCC:Pathology |
| مصطلحات موضوعية: | metabolomics, point-of-care test, conducting polymer spray ionization, saliva metabolomics, severe periodontitis (Stage IV and Grade C), Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Pathology, RB1-214 |
| الوصف: | Saliva is a noninvasive biofluid that contains the metabolic signature of severe periodontitis (SP, Stage IV and Grade C). Conductive polymer spray ionization mass spectrometry (CPSI-MS) was used to record a wide range of metabolites within a few seconds, making this technique a promising point-of-care method for the early detection of SP (Stage IV and Grade C). Saliva samples from 31 volunteers, consisting of 16 healthy controls (HC) and 15 patients with SP (Stage IV and Grade C), were collected to identify dysregulated metabolites. Twenty metabolites were screened out, including seven amino acids. Moreover, the results showed that amino acid metabolism is closely related to the development of periodontitis. The present study further confirmed that salivary metabolites in the oral cavity were significantly altered after plaque removal. These results suggest that the combination of CPSI-MS is a feasible tool for preclinical screening of SP (Stage IV and Grade C). |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1532-2807 |
| Relation: | https://www.por-journal.com/articles/10.3389/pore.2022.1610739/full; https://doaj.org/toc/1532-2807 |
| DOI: | 10.3389/pore.2022.1610739 |
| URL الوصول: | https://doaj.org/article/9e9a779f9dad42df88c127d1a8b006d4 |
| رقم الأكسشن: | edsdoj.9e9a779f9dad42df88c127d1a8b006d4 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 15322807 |
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| DOI: | 10.3389/pore.2022.1610739 |