دورية أكاديمية
أعرض في EDS

Construction and In Vitro Evaluation of a Tumor Acidic pH-Targeting Drug Delivery System Based on Escherichia coli Nissle 1917 Bacterial Ghosts

التفاصيل البيبلوغرافية
العنوان: Construction and In Vitro Evaluation of a Tumor Acidic pH-Targeting Drug Delivery System Based on Escherichia coli Nissle 1917 Bacterial Ghosts
المؤلفون: Yi Ma, Qiying Liu, Aihua Hu, Shoujin Jiang, Sijia Wang, Ran Liu, Kun Han, Jufang Wang
المصدر: Bioengineering, Vol 9, Iss 9, p 433 (2022)
بيانات النشر: MDPI AG, 2022.
سنة النشر: 2022
المجموعة: LCC:Technology
LCC:Biology (General)
مصطلحات موضوعية: bacterial ghosts, drug delivery system, phage α3, Lpp-OmpA displays system, ATRAM, Technology, Biology (General), QH301-705.5
الوصف: Synthetic nanocarriers are a promising therapeutic delivery strategy. However, these systems are often hampered by inherent disadvantages such as strong biotoxicity and poor biocompatibility. To overcome these issues, biological carriers with commonly used chemotherapy drugs have been developed. In this work, engineered bacterial ghosts (BGs) originated from probiotic Escherichia coli Nissle 1917 (EcN) were devised to specifically target acidic extracellular environments of tumor tissue. To improve the production efficiency and safety, a novel lysis protein E from phage α3 was applied to produce EcN BGs under high growth densities in high quality. In addition, the acidity-triggered rational membrane (ATRAM) peptides were displayed in EcN BGs to facilitate specific cancer cell internalization within the acidic tumor microenvironment before drug release. In conclusion, the engineered EcN BGs offer a promising means for bionic bacteria construction for hepatocellular carcinoma therapy.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2306-5354
Relation: https://www.mdpi.com/2306-5354/9/9/433; https://doaj.org/toc/2306-5354
DOI: 10.3390/bioengineering9090433
URL الوصول: https://doaj.org/article/9eaf667282af4c9c98fdca9e146243fc
رقم الأكسشن: edsdoj.9eaf667282af4c9c98fdca9e146243fc
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:23065354
DOI:10.3390/bioengineering9090433