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Analysis of Corticosteroid-Induced Glaucoma Using the Japanese Adverse Drug Event Reporting Database

التفاصيل البيبلوغرافية
العنوان: Analysis of Corticosteroid-Induced Glaucoma Using the Japanese Adverse Drug Event Reporting Database
المؤلفون: Ayano Kawabe, Yoshihiro Uesawa
المصدر: Pharmaceuticals, Vol 16, Iss 7, p 948 (2023)
بيانات النشر: MDPI AG, 2023.
سنة النشر: 2023
المجموعة: LCC:Medicine
LCC:Pharmacy and materia medica
مصطلحات موضوعية: glaucoma, corticosteroids, intraocular pressure, Japanese Adverse Drug Event Report (JADER) database, spontaneous reporting system, volcano plot, Medicine, Pharmacy and materia medica, RS1-441
الوصف: Glaucoma is the most common cause of blindness, which significantly reduces quality of life. Most glaucoma cases are primary glaucoma; nevertheless, many patients suffer from glaucoma caused by drugs, such as corticosteroids. A comprehensive review of the risks associated with corticosteroid-induced glaucoma is limited. Therefore, we used the Japanese Adverse Drug Event Reporting Database (JADER) published by the Pharmaceuticals and Medical Devices Agency (PMDA) to analyze the risk factors associated with glaucoma and the trends and characteristics of corticosteroid-induced glaucoma. We did not find sex or age differences associated with the onset of glaucoma. Hierarchical clustering and principal component analysis revealed that triamcinolone acetonide and betamethasone sodium phosphate, which are used around the eyes in Japan, are more likely to induce intraocular pressure (IOP) elevation compared with other corticosteroids. Increased IOP is a direct cause of glaucoma. Based on these findings, it may be necessary to limit or avoid the use of these corticosteroids.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1424-8247
Relation: https://www.mdpi.com/1424-8247/16/7/948; https://doaj.org/toc/1424-8247
DOI: 10.3390/ph16070948
URL الوصول: https://doaj.org/article/a9ee6e99a20c4adab65e3840688e4694
رقم الأكسشن: edsdoj.9ee6e99a20c4adab65e3840688e4694
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14248247
DOI:10.3390/ph16070948