دورية أكاديمية
Analysis of Corticosteroid-Induced Glaucoma Using the Japanese Adverse Drug Event Reporting Database
العنوان: | Analysis of Corticosteroid-Induced Glaucoma Using the Japanese Adverse Drug Event Reporting Database |
---|---|
المؤلفون: | Ayano Kawabe, Yoshihiro Uesawa |
المصدر: | Pharmaceuticals, Vol 16, Iss 7, p 948 (2023) |
بيانات النشر: | MDPI AG, 2023. |
سنة النشر: | 2023 |
المجموعة: | LCC:Medicine LCC:Pharmacy and materia medica |
مصطلحات موضوعية: | glaucoma, corticosteroids, intraocular pressure, Japanese Adverse Drug Event Report (JADER) database, spontaneous reporting system, volcano plot, Medicine, Pharmacy and materia medica, RS1-441 |
الوصف: | Glaucoma is the most common cause of blindness, which significantly reduces quality of life. Most glaucoma cases are primary glaucoma; nevertheless, many patients suffer from glaucoma caused by drugs, such as corticosteroids. A comprehensive review of the risks associated with corticosteroid-induced glaucoma is limited. Therefore, we used the Japanese Adverse Drug Event Reporting Database (JADER) published by the Pharmaceuticals and Medical Devices Agency (PMDA) to analyze the risk factors associated with glaucoma and the trends and characteristics of corticosteroid-induced glaucoma. We did not find sex or age differences associated with the onset of glaucoma. Hierarchical clustering and principal component analysis revealed that triamcinolone acetonide and betamethasone sodium phosphate, which are used around the eyes in Japan, are more likely to induce intraocular pressure (IOP) elevation compared with other corticosteroids. Increased IOP is a direct cause of glaucoma. Based on these findings, it may be necessary to limit or avoid the use of these corticosteroids. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1424-8247 |
Relation: | https://www.mdpi.com/1424-8247/16/7/948; https://doaj.org/toc/1424-8247 |
DOI: | 10.3390/ph16070948 |
URL الوصول: | https://doaj.org/article/a9ee6e99a20c4adab65e3840688e4694 |
رقم الأكسشن: | edsdoj.9ee6e99a20c4adab65e3840688e4694 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 14248247 |
---|---|
DOI: | 10.3390/ph16070948 |