دورية أكاديمية
Loss of FoxOs in muscle increases strength and mitochondrial function during aging
| العنوان: | Loss of FoxOs in muscle increases strength and mitochondrial function during aging |
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| المؤلفون: | Christie M. Penniman, Gourav Bhardwaj, Colette J. Nowers, Chandler U. Brown, Taylor L. Junck, Cierra K. Boyer, Jayashree Jena, Jordan D. Fuqua, Vitor A. Lira, Brian T. O'Neill |
| المصدر: | Journal of Cachexia, Sarcopenia and Muscle, Vol 14, Iss 1, Pp 243-259 (2023) |
| بيانات النشر: | Wiley, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Diseases of the musculoskeletal system LCC:Human anatomy |
| مصطلحات موضوعية: | FoxO, Aging, Mitochondrial function, Insulin resistance, Muscle hypertrophy, Glucose tolerance, Diseases of the musculoskeletal system, RC925-935, Human anatomy, QM1-695 |
| الوصف: | Abstract Background Muscle mitochondrial decline is associated with aging‐related muscle weakness and insulin resistance. FoxO transcription factors are targets of insulin action and deletion of FoxOs improves mitochondrial function in diabetes. However, disruptions in proteostasis and autophagy are hallmarks of aging and the effect of chronic inhibition of FoxOs in aged muscle is unknown. This study investigated the role of FoxOs in regulating muscle strength and mitochondrial function with age. Methods We measured muscle strength, cross‐sectional area, muscle fibre‐type, markers of protein synthesis/degradation, central nuclei, glucose/insulin tolerance, and mitochondrial bioenergetics in 4.5‐month (Young) and 22–24‐month‐old (Aged) muscle‐specific FoxO1/3/4 triple KO (TKO) and littermate control (Ctrl) mice. Results Lean mass was increased in Aged TKO compared with both Aged Ctrl and younger groups by 26–33% (P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2190-6009 2190-5991 |
| Relation: | https://doaj.org/toc/2190-5991; https://doaj.org/toc/2190-6009 |
| DOI: | 10.1002/jcsm.13124 |
| URL الوصول: | https://doaj.org/article/c9f129a6962c4f9aa5ecf446caaba8e4 |
| رقم الأكسشن: | edsdoj.9f129a6962c4f9aa5ecf446caaba8e4 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 21906009 21905991 |
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| DOI: | 10.1002/jcsm.13124 |