Membrane distillation (MD) is a separation technology for many industries including desalination, pharmaceuticals, and food processing. However, MD technology readiness has not reached the required level to penetrate the desalination and water treatment market. One of the challenges to commercialization is the limited development and inaccurate assessment of MD-specific membranes. In fact, measuring the performance of MD membranes is challenging because it is dependent on process parameters, making it difficult to separate the individual influences of the process operating conditions and the membranes’ intrinsic properties. These shortcomings drive the need for a standardized methodology to compare and report membrane performance independently of the process parameters. In this work, we propose a standardized methodology for measuring the permeance of MD membranes using a reduced scale direct contact membrane distillation (DCMD) setup. This methodology has the potential to streamline membrane assessment and support ongoing efforts in MD membrane development and process scale-up.