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Multi-tissue epigenetic analysis identifies distinct associations underlying insulin resistance and Alzheimer’s disease at CPT1A locus

التفاصيل البيبلوغرافية
العنوان: Multi-tissue epigenetic analysis identifies distinct associations underlying insulin resistance and Alzheimer’s disease at CPT1A locus
المؤلفون: Chloé Sarnowski, Tianxiao Huan, Yiyi Ma, Roby Joehanes, Alexa Beiser, Charles S. DeCarli, Nancy L. Heard-Costa, Daniel Levy, Honghuang Lin, Ching-Ti Liu, Chunyu Liu, James B. Meigs, Claudia L. Satizabal, Jose C. Florez, Marie-France Hivert, Josée Dupuis, Philip L. De Jager, David A. Bennett, Sudha Seshadri, Alanna C. Morrison
المصدر: Clinical Epigenetics, Vol 15, Iss 1, Pp 1-17 (2023)
بيانات النشر: BMC, 2023.
سنة النشر: 2023
المجموعة: LCC:Medicine
LCC:Genetics
مصطلحات موضوعية: Epigenetics, Insulin resistance, Alzheimer’s disease, FHS, ROSMAP, DNA methylation, Medicine, Genetics, QH426-470
الوصف: Abstract Background Insulin resistance (IR) is a major risk factor for Alzheimer’s disease (AD) dementia. The mechanisms by which IR predisposes to AD are not well-understood. Epigenetic studies may help identify molecular signatures of IR associated with AD, thus improving our understanding of the biological and regulatory mechanisms linking IR and AD. Methods We conducted an epigenome-wide association study of IR, quantified using the homeostatic model assessment of IR (HOMA-IR) and adjusted for body mass index, in 3,167 participants from the Framingham Heart Study (FHS) without type 2 diabetes at the time of blood draw used for methylation measurement. We identified DNA methylation markers associated with IR at the genome-wide level accounting for multiple testing (P
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1868-7083
Relation: https://doaj.org/toc/1868-7083
DOI: 10.1186/s13148-023-01589-4
URL الوصول: https://doaj.org/article/d9f552a1cc0842fc826edbb499f07475
رقم الأكسشن: edsdoj.9f552a1cc0842fc826edbb499f07475
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:18687083
DOI:10.1186/s13148-023-01589-4