دورية أكاديمية
Multi-tissue epigenetic analysis identifies distinct associations underlying insulin resistance and Alzheimer’s disease at CPT1A locus
العنوان: | Multi-tissue epigenetic analysis identifies distinct associations underlying insulin resistance and Alzheimer’s disease at CPT1A locus |
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المؤلفون: | Chloé Sarnowski, Tianxiao Huan, Yiyi Ma, Roby Joehanes, Alexa Beiser, Charles S. DeCarli, Nancy L. Heard-Costa, Daniel Levy, Honghuang Lin, Ching-Ti Liu, Chunyu Liu, James B. Meigs, Claudia L. Satizabal, Jose C. Florez, Marie-France Hivert, Josée Dupuis, Philip L. De Jager, David A. Bennett, Sudha Seshadri, Alanna C. Morrison |
المصدر: | Clinical Epigenetics, Vol 15, Iss 1, Pp 1-17 (2023) |
بيانات النشر: | BMC, 2023. |
سنة النشر: | 2023 |
المجموعة: | LCC:Medicine LCC:Genetics |
مصطلحات موضوعية: | Epigenetics, Insulin resistance, Alzheimer’s disease, FHS, ROSMAP, DNA methylation, Medicine, Genetics, QH426-470 |
الوصف: | Abstract Background Insulin resistance (IR) is a major risk factor for Alzheimer’s disease (AD) dementia. The mechanisms by which IR predisposes to AD are not well-understood. Epigenetic studies may help identify molecular signatures of IR associated with AD, thus improving our understanding of the biological and regulatory mechanisms linking IR and AD. Methods We conducted an epigenome-wide association study of IR, quantified using the homeostatic model assessment of IR (HOMA-IR) and adjusted for body mass index, in 3,167 participants from the Framingham Heart Study (FHS) without type 2 diabetes at the time of blood draw used for methylation measurement. We identified DNA methylation markers associated with IR at the genome-wide level accounting for multiple testing (P |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1868-7083 |
Relation: | https://doaj.org/toc/1868-7083 |
DOI: | 10.1186/s13148-023-01589-4 |
URL الوصول: | https://doaj.org/article/d9f552a1cc0842fc826edbb499f07475 |
رقم الأكسشن: | edsdoj.9f552a1cc0842fc826edbb499f07475 |
قاعدة البيانات: | Directory of Open Access Journals |
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