دورية أكاديمية
Preparation and In-Vitro Evaluation as an Oral Microsponge Tablet of Baclofen
| العنوان: | Preparation and In-Vitro Evaluation as an Oral Microsponge Tablet of Baclofen |
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| المؤلفون: | Faten Ibraheem Alatraqchi, Fatima J. AL Gawhri |
| المصدر: | Iraqi Journal of Pharmaceutical Sciences, Vol 28, Iss 1 (2019) |
| بيانات النشر: | College of Pharmacy University of Baghdad, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Pharmacy and materia medica |
| مصطلحات موضوعية: | baclofen, microsponge, Pharmacy and materia medica, RS1-441 |
| الوصف: | The aim of the present study is to formulate floating effervescent microsponge tablet of the narrow absorption window drug, Baclofen (BFN) for controlling drug release and thereby decrease the side effect of the drug. The microsponges of BFN were prepared by non-aqueous emulsion solvent diffusion method (oil in oil emulsion method). The effects of drug: polymer ratio, stirring time and type of Eudragit polymer on the physical characteristics of microsponges were investigated and characterized for production yield, loading efficiency, particle size, surface morphology, and in vitro drug release from microsponges. The selected microsponge formula was incorporated into the floating effervescent gastro-retentive tablet. The prepared floating microsponge tablet was evaluated for tablet hardness, friability, swelling in addition to in vitro drug release. The results showed that the microsponge formula with Eudragit RS100 had optimum physical properties and controlled drug release (75% of drug release in 8 hr.) when compared with other formulas and pure baclofen. The oil in oil emulsion method is a promising method to produce baclofen microsponge. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2521-3512 1683-3597 |
| Relation: | https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/809; https://doaj.org/toc/2521-3512; https://doaj.org/toc/1683-3597 |
| DOI: | 10.31351/vol28iss1pp75-90 |
| URL الوصول: | https://doaj.org/article/cc9f5ca2d1624bf8b72273fff486135e |
| رقم الأكسشن: | edsdoj.9f5ca2d1624bf8b72273fff486135e |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 25213512 16833597 |
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| DOI: | 10.31351/vol28iss1pp75-90 |