دورية أكاديمية
The non-mitotic role of HMMR in regulating the localization of TPX2 and the dynamics of microtubules in neurons
| العنوان: | The non-mitotic role of HMMR in regulating the localization of TPX2 and the dynamics of microtubules in neurons |
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| المؤلفون: | Yi-Ju Chen, Shun-Cheng Tseng, Peng-Tzu Chen, Eric Hwang |
| المصدر: | eLife, Vol 13 (2024) |
| بيانات النشر: | eLife Sciences Publications Ltd, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine LCC:Science LCC:Biology (General) |
| مصطلحات موضوعية: | +tips, branching, nucleation, outgrowth, mouse, Medicine, Science, Biology (General), QH301-705.5 |
| الوصف: | A functional nervous system is built upon the proper morphogenesis of neurons to establish the intricate connection between them. The microtubule cytoskeleton is known to play various essential roles in this morphogenetic process. While many microtubule-associated proteins (MAPs) have been demonstrated to participate in neuronal morphogenesis, the function of many more remains to be determined. This study focuses on a MAP called HMMR in mice, which was originally identified as a hyaluronan binding protein and later found to possess microtubule and centrosome binding capacity. HMMR exhibits high abundance on neuronal microtubules and altering the level of HMMR significantly affects the morphology of neurons. Instead of confining to the centrosome(s) like cells in mitosis, HMMR localizes to microtubules along axons and dendrites. Furthermore, transiently expressing HMMR enhances the stability of neuronal microtubules and increases the formation frequency of growing microtubules along the neurites. HMMR regulates the microtubule localization of a non-centrosomal microtubule nucleator TPX2 along the neurite, offering an explanation for how HMMR contributes to the promotion of growing microtubules. This study sheds light on how cells utilize proteins involved in mitosis for non-mitotic functions. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2050-084X |
| Relation: | https://elifesciences.org/articles/94547; https://doaj.org/toc/2050-084X |
| DOI: | 10.7554/eLife.94547 |
| URL الوصول: | https://doaj.org/article/9f7d289e829545088d5262b3431d2874 |
| رقم الأكسشن: | edsdoj.9f7d289e829545088d5262b3431d2874 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2050084X |
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| DOI: | 10.7554/eLife.94547 |