دورية أكاديمية
Macrolide antibiotics activate the integrated stress response and promote tumor proliferation
| العنوان: | Macrolide antibiotics activate the integrated stress response and promote tumor proliferation |
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| المؤلفون: | Xin Yu, Ai-Ling Tian, Ping Wang, Juanjuan Li, Juan Wu, Bei Li, Zhou Liu, Siqing Liu, Zhijie Gao, Si Sun, Shengrong Sun, Yi Tu, Qi Wu |
| المصدر: | Cell Stress, Vol 7, Iss 4, Pp 20-33 (2023) |
| بيانات النشر: | Shared Science Publishers OG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine LCC:Biology (General) |
| مصطلحات موضوعية: | macrolide antibiotic, azithromycin, autophagy, ros, er stress, cancer, Medicine, Biology (General), QH301-705.5 |
| الوصف: | Macrolide antibiotics are widely used antibacterial agents that are associated with autophagy inhibition. This study aimed to investigate the association between macrolide antibi-otics and malignant tumors, as well as the effect on autophagy, reactive oxygen species (ROS) accumulation and integrated stress response (ISR). The meta-analysis indicated a modestly higher risk of cancer in macrolide antibiotic ever-users com-pared to non-users. Further experiments showed that macro-lides block autophagic flux by inhibiting lysosomal acidification. Additionally, azithromycin, a representative macrolide antibi-otic, induced the accumulation of ROS, and stimulated the ISR and the activation of transcription factor EB (TFEB) and TFE3 in a ROS-dependent manner. Finally, animal experiments confirmed that azithromycin promoted tumor progression in vivo, which could be receded by N-acetylcysteine, an inhibitor of ROS and ISR. Overall, this study reveals the potential role of macrolide antibiotics in malignant progression and highlights the need for further investigation into their effects. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2523-0204 |
| Relation: | http://www.cell-stress.com/researcharticles/2023a-yu-cell-stress/; https://doaj.org/toc/2523-0204 |
| DOI: | 10.15698/cst2023.04.278 |
| URL الوصول: | https://doaj.org/article/9fa465f30f3148a785c8cd5ca98ecab8 |
| رقم الأكسشن: | edsdoj.9fa465f30f3148a785c8cd5ca98ecab8 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 25230204 |
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| DOI: | 10.15698/cst2023.04.278 |