دورية أكاديمية
Comparison Shows that Multiplex Polymerase Chain Reaction Identifies Infection-associated Urinary Biomarker–positive Urinary Tract Infections That Are Missed by Standard Urine Culture
| العنوان: | Comparison Shows that Multiplex Polymerase Chain Reaction Identifies Infection-associated Urinary Biomarker–positive Urinary Tract Infections That Are Missed by Standard Urine Culture |
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| المؤلفون: | Emery Haley, Natalie Luke, Mohit Mathur, Richard A. Festa, Jimin Wang, Yan Jiang, Lori Anderson, David Baunoch |
| المصدر: | European Urology Open Science, Vol 58, Iss , Pp 73-81 (2023) |
| بيانات النشر: | Elsevier, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Diseases of the genitourinary system. Urology LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | Urinary tract infection, Standard urine culture, Diagnostic testing, Multiplex polymerase chain reaction, Urine biomarkers, False negative urine culture, Diseases of the genitourinary system. Urology, RC870-923, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Background: Multiplex polymerase chain reaction (M-PCR) has increased sensitivity for microbial detection compared with standard urine culture (SUC) in cases diagnosed as urinary tract infections (UTIs), leading to questions whether detected microbes are likely causative of UTIs or are incidental findings. Objective: To compare infection-associated biomarker levels against M-PCR and SUC results in symptomatic cases with a presumptive diagnosis of a UTI by a urologist. Design, setting, and participants: Participants were ≥60 yr old and presented to urology clinics between January and April 2023 with symptoms of UTIs (n = 583). Urine microbial detection was by M-PCR and SUC. Three infection-associated biomarkers (neutrophil gelatinase-associated lipocalin, interleukin-8, and interleukin-1β) were measured by enzyme-linked immunosorbent assay. Symptomatic cases with elevated biomarkers, detection of uropathogens, and a specialist clinical diagnosis of a UTI were considered definitive UTI cases. Outcome measurements and statistical analysis: Distributions were compared using two-sample Wilcoxon rank sum test, with two-tailed p values of |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2666-1683 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2666168323018074; https://doaj.org/toc/2666-1683 |
| DOI: | 10.1016/j.euros.2023.10.008 |
| URL الوصول: | https://doaj.org/article/9fa7bd647e954a86b8d9967368c32d3a |
| رقم الأكسشن: | edsdoj.9fa7bd647e954a86b8d9967368c32d3a |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 26661683 |
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| DOI: | 10.1016/j.euros.2023.10.008 |