دورية أكاديمية
A combined immunopeptidomics, proteomics, and cell surface proteomics approach to identify immunotherapy targets for diffuse intrinsic pontine glioma
| العنوان: | A combined immunopeptidomics, proteomics, and cell surface proteomics approach to identify immunotherapy targets for diffuse intrinsic pontine glioma |
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| المؤلفون: | Kirti Pandey, Stacie S. Wang, Nicole A. Mifsud, Pouya Faridi, Alexander J. Davenport, Andrew I. Webb, Jarrod J. Sandow, Rochelle Ayala, Michelle Monje, Ryan S. Cross, Sri H. Ramarathinam, Misty R. Jenkins, Anthony W. Purcell |
| المصدر: | Frontiers in Oncology, Vol 13 (2023) |
| بيانات النشر: | Frontiers Media S.A., 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | DIPG, paediatric brain cancer, proteomics, surfaceome, HLA, immunopeptidomics, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | IntroductionDiffuse intrinsic pontine glioma (DIPG), recently reclassified as a subtype of diffuse midline glioma, is a highly aggressive brainstem tumor affecting children and young adults, with no cure and a median survival of only 9 months. Conventional treatments are ineffective, highlighting the need for alternative therapeutic strategies such as cellular immunotherapy. However, identifying unique and tumor-specific cell surface antigens to target with chimeric antigen receptor (CAR) or T-cell receptor (TCR) therapies is challenging.MethodsIn this study, a multi-omics approach was used to interrogate patient-derived DIPG cell lines and to identify potential targets for immunotherapy.ResultsThrough immunopeptidomics, a range of targetable peptide antigens from cancer testis and tumor-associated antigens as well as peptides derived from human endogenous retroviral elements were identified. Proteomics analysis also revealed upregulation of potential drug targets and cell surface proteins such as Cluster of differentiation 27 (CD276) B7 homolog 3 protein (B7H3), Interleukin 13 alpha receptor 2 (IL-13Rα2), Human Epidermal Growth Factor Receptor 3 (HER2), Ephrin Type-A Receptor 2 (EphA2), and Ephrin Type-A Receptor 3 (EphA3).DiscussionThe results of this study provide a valuable resource for the scientific community to accelerate immunotherapeutic approaches for DIPG. Identifying potential targets for CAR and TCR therapies could open up new avenues for treating this devastating disease. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2234-943X 64829693 |
| Relation: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1192448/full; https://doaj.org/toc/2234-943X |
| DOI: | 10.3389/fonc.2023.1192448 |
| URL الوصول: | https://doaj.org/article/cca9faeeedb64a64829693d53680c424 |
| رقم الأكسشن: | edsdoj.9faeeedb64a64829693d53680c424 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2234943X 64829693 |
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| DOI: | 10.3389/fonc.2023.1192448 |