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Study on the Regulation Effect of Optogenetic Technology on LFP of the Basal Ganglia Nucleus in Rotenone-Treated Rats

التفاصيل البيبلوغرافية
العنوان: Study on the Regulation Effect of Optogenetic Technology on LFP of the Basal Ganglia Nucleus in Rotenone-Treated Rats
المؤلفون: Zongya Zhao, Yanxiang Niu, Peiqi Chen, Yu Zhu, Liangliang Shi, Xuewei Zhao, Chang Wang, Yehong Zhang, Zhixian Gao, Wenshuai Jiang, Wu Ren, Renjun Gu, Yi Yu
المصدر: Neural Plasticity, Vol 2021 (2021)
بيانات النشر: Hindawi Limited, 2021.
سنة النشر: 2021
المجموعة: LCC:Neurosciences. Biological psychiatry. Neuropsychiatry
مصطلحات موضوعية: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
الوصف: Background. Parkinson’s disease (PD) is a common neurological degenerative disease that cannot be completely cured, although drugs can improve or alleviate its symptoms. Optogenetic technology, which stimulates or inhibits neurons with excellent spatial and temporal resolution, provides a new idea and approach for the precise treatment of Parkinson’s disease. However, the neural mechanism of photogenetic regulation remains unclear. Objective. In this paper, we want to study the nonlinear features of EEG signals in the striatum and globus pallidus through optogenetic stimulation of the substantia nigra compact part. Methods. Rotenone was injected stereotactically into the substantia nigra compact area and ventral tegmental area of SD rats to construct rotenone-treated rats. Then, for the optogenetic manipulation, we injected adeno-associated virus expressing channelrhodopsin to stimulate the globus pallidus and the striatum with a 1 mW blue light and collected LFP signals before, during, and after light stimulation. Finally, the collected LFP signals were analyzed by using nonlinear dynamic algorithms. Results. After observing the behavior and brain morphology, 16 models were finally determined to be successful. LFP results showed that approximate entropy and fractal dimension of rats in the control group were significantly greater than those in the experimental group after light treatment (p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2090-5904
1687-5443
Relation: https://doaj.org/toc/2090-5904; https://doaj.org/toc/1687-5443
DOI: 10.1155/2021/9938566
URL الوصول: https://doaj.org/article/e9fe60147aa647b9996b2a5bc3215531
رقم الأكسشن: edsdoj.9fe60147aa647b9996b2a5bc3215531
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20905904
16875443
DOI:10.1155/2021/9938566