دورية أكاديمية
Does a nephron deficit exacerbate the renal and cardiovascular effects of obesity?
| العنوان: | Does a nephron deficit exacerbate the renal and cardiovascular effects of obesity? |
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| المؤلفون: | Seshini Gurusinghe, Russell D Brown, Xiaochu Cai, Chrishan S Samuel, Sharon D Ricardo, Merlin C Thomas, Michelle M Kett |
| المصدر: | PLoS ONE, Vol 8, Iss 9, p e73095 (2013) |
| بيانات النشر: | Public Library of Science (PLoS), 2013. |
| سنة النشر: | 2013 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | It has been hypothesized that a reduced nephron endowment exacerbates the hypertensive and renal effects of obesity. We therefore examined the impact of diet-induced obesity on renal structure and function, and arterial pressure in a genetic model of reduced nephron endowment, the GDNF Heterozygous (HET) mouse. 6 wk-old male GDNF WT and HET mice were placed on control or high fat (HFF) diet for 20 weeks. 24 hr arterial pressure, heart rate and activity (radiotelemetry), creatinine clearance and albumin excretion were measured, and kidneys collected (histopathology, collagen content). Bodyweights of HFF WT (50.6 ± 1.2 g) and HET (48.8 ± 1.4 g) mice were ∼14 g greater than control mice (37.3 ± 1.3 g, 36.4 ± 1.1 g respectively; Pdiet |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1932-6203 |
| Relation: | http://europepmc.org/articles/PMC3760915?pdf=render; https://doaj.org/toc/1932-6203 |
| DOI: | 10.1371/journal.pone.0073095 |
| URL الوصول: | https://doaj.org/article/b021279cbf80424f8e790e17ab0ee7e0 |
| رقم الأكسشن: | edsdoj.b021279cbf80424f8e790e17ab0ee7e0 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0073095 |