دورية أكاديمية
Regio- and stereoselective oxidation of unactivated C–H bonds with Rhodococcus rhodochrous
| العنوان: | Regio- and stereoselective oxidation of unactivated C–H bonds with Rhodococcus rhodochrous |
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| المؤلفون: | Elaine O’Reilly, Suzanne J. Aitken, Gideon Grogan, Paul P. Kelly, Nicholas J. Turner, Sabine L. Flitsch |
| المصدر: | Beilstein Journal of Organic Chemistry, Vol 8, Iss 1, Pp 496-500 (2012) |
| بيانات النشر: | Beilstein-Institut, 2012. |
| سنة النشر: | 2012 |
| المجموعة: | LCC:Science LCC:Organic chemistry |
| مصطلحات موضوعية: | biocatalysis, cytochrome P450, hydroxylation, Rhodococcus rhodochrous, selective C–H activation, Science, Organic chemistry, QD241-441 |
| الوصف: | The ability of Rhodococcus rhodochrous (NCIMB 9703) to catalyse the regio- and stereoselective hydroxylation of a range of benzyloxy-substituted heterocycles has been investigated. Incubation of 2-benzyloxytetrahydropyrans with resting cell suspensions of the organism yielded predominantly a mixture of 5-hydroxylated isomers in combined yields of up to 40%. Exposure of the corresponding 2-benzyloxytetrahydrofuran derivatives to the cell suspensions gave predominantly the 4-hydroxylated isomers in yields of up to 26%. Most interestingly, 2-(4-nitrobenzyloxy)tetrahydrofuran and 2-(4-nitrobenzyloxy)tetrahydropyran were transformed in high yields to the 4-hydroxylated and 5-hydroxylated products, respectively. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1860-5397 |
| Relation: | https://doaj.org/toc/1860-5397 |
| DOI: | 10.3762/bjoc.8.56 |
| URL الوصول: | https://doaj.org/article/b02b817aa61845d582b500b249b1ba9c |
| رقم الأكسشن: | edsdoj.b02b817aa61845d582b500b249b1ba9c |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 18605397 |
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| DOI: | 10.3762/bjoc.8.56 |