دورية أكاديمية
A Modular Mathematical Model of Exercise-Induced Changes in Metabolism, Signaling, and Gene Expression in Human Skeletal Muscle
| العنوان: | A Modular Mathematical Model of Exercise-Induced Changes in Metabolism, Signaling, and Gene Expression in Human Skeletal Muscle |
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| المؤلفون: | Ilya R. Akberdin, Ilya N. Kiselev, Sergey S. Pintus, Ruslan N. Sharipov, Alexander Yu Vertyshev, Olga L. Vinogradova, Daniil V. Popov, Fedor A. Kolpakov |
| المصدر: | International Journal of Molecular Sciences, Vol 22, Iss 19, p 10353 (2021) |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | mathematical model, skeletal muscle, physical exercise, Ca2+-dependent signaling pathway, transcriptome, RNA sequencing, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Skeletal muscle is the principal contributor to exercise-induced changes in human metabolism. Strikingly, although it has been demonstrated that a lot of metabolites accumulating in blood and human skeletal muscle during an exercise activate different signaling pathways and induce the expression of many genes in working muscle fibres, the systematic understanding of signaling–metabolic pathway interrelations with downstream genetic regulation in the skeletal muscle is still elusive. Herein, a physiologically based computational model of skeletal muscle comprising energy metabolism, Ca2+, and AMPK (AMP-dependent protein kinase) signaling pathways and the expression regulation of genes with early and delayed responses was developed based on a modular modeling approach and included 171 differential equations and more than 640 parameters. The integrated modular model validated on diverse including original experimental data and different exercise modes provides a comprehensive in silico platform in order to decipher and track cause–effect relationships between metabolic, signaling, and gene expression levels in skeletal muscle. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/22/19/10353; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms221910353 |
| URL الوصول: | https://doaj.org/article/b039599255d943b7badfb29eb21af32c |
| رقم الأكسشن: | edsdoj.b039599255d943b7badfb29eb21af32c |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms221910353 |