دورية أكاديمية
Investigation of multiple susceptibility loci for inflammatory bowel disease in an Italian cohort of patients.
العنوان: | Investigation of multiple susceptibility loci for inflammatory bowel disease in an Italian cohort of patients. |
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المؤلفون: | Anna Latiano, Orazio Palmieri, Tiziana Latiano, Giuseppe Corritore, Fabrizio Bossa, Giuseppina Martino, Giuseppe Biscaglia, Daniela Scimeca, Maria Rosa Valvano, Maria Pastore, Antonio Marseglia, Renata D'Incà, Angelo Andriulli, Vito Annese |
المصدر: | PLoS ONE, Vol 6, Iss 7, p e22688 (2011) |
بيانات النشر: | Public Library of Science (PLoS), 2011. |
سنة النشر: | 2011 |
المجموعة: | LCC:Medicine LCC:Science |
مصطلحات موضوعية: | Medicine, Science |
الوصف: | BACKGROUND: Recent GWAs and meta-analyses have outlined about 100 susceptibility genes/loci for inflammatory bowel diseases (IBD). In this study we aimed to investigate the influence of SNPs tagging the genes/loci PTGER4, TNFSF15, NKX2-3, ZNF365, IFNG, PTPN2, PSMG1, and HLA in a large pediatric- and adult-onset IBD Italian cohort. METHODS: Eight SNPs were assessed in 1,070 Crohn's disease (CD), 1,213 ulcerative colitis (UC), 557 of whom being diagnosed at the age of ≤16 years, and 789 healthy controls. Correlations with sub-phenotypes and major variants of NOD2 gene were investigated. RESULTS: The SNPs tagging the TNFSF15, NKX2-3, ZNF365, and PTPN2 genes were associated with CD (P values ranging from 0.037 to 7×10(-6)). The SNPs tagging the PTGER4, NKX2-3, ZNF365, IFNG, PSMG1, and HLA area were associated with UC (P values 0.047 to 4×10(-5)). In the pediatric cohort the associations of TNFSF15, NKX2-3 with CD, and PTGER4, NKX2-3, ZNF365, IFNG, PSMG1 with UC, were confirmed. Association with TNFSF15 and pediatric UC was also reported. A correlation with NKX2-3 and need for surgery (P = 0.038), and with HLA and steroid-responsiveness (P = 0.024) in UC patients was observed. Moreover, significant association in our CD cohort with TNFSF15 SNP and colonic involvement (P = 0.021), and with ZNF365 and ileal location (P = 0.024) was demonstrated. CONCLUSIONS: We confirmed in a large Italian cohort the associations with CD and UC of newly identified genes, both in adult and pediatric cohort of patients, with some influence on sub-phenotypes. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1932-6203 |
Relation: | http://europepmc.org/articles/PMC3144927?pdf=render; https://doaj.org/toc/1932-6203 |
DOI: | 10.1371/journal.pone.0022688 |
URL الوصول: | https://doaj.org/article/b07927a54c3141eea507c9555e3c8990 |
رقم الأكسشن: | edsdoj.b07927a54c3141eea507c9555e3c8990 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 19326203 |
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DOI: | 10.1371/journal.pone.0022688 |