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YANK2 activated by Fyn promotes glioma tumorigenesis via the mTOR-independent p70S6K activation pathway

التفاصيل البيبلوغرافية
العنوان: YANK2 activated by Fyn promotes glioma tumorigenesis via the mTOR-independent p70S6K activation pathway
المؤلفون: Yue Shi, Yue Cheng, Wei Wang, Liu Tang, Wensheng Li, Liyuan Zhang, Zheng Yuan, Feng Zhu, Qiuhong Duan
المصدر: Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
بيانات النشر: Nature Portfolio, 2024.
سنة النشر: 2024
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: YANK2, Glioma, Fyn, p70S6K, Tumorigenesis, Medicine, Science
الوصف: Abstract Glioma, particularly glioblastomas (GBM), is incurable brain tumor. The most targeted receptor tyrosine kinase (RTKs) drugs did not bring benefit to GBM patients. The mechanism of glioma growth continues to be explored to find more effective treatment. Here, we reported that Ser/Thr protein kinase YANK2 (yet another kinase 2) is upregulated in glioma tissues and promotes the growth and proliferation of glioma in vitro and in vivo. Further, we confirmed that oncogene Fyn directly activated YANK2 through phosphorylation its Y110, and Fyn-mediated YANK2 phosphorylation at Y110 site promotes glioma growth by increasing its stability. Finally, YANK2 was proved to be a novel upstream kinase of p70S6K and promotes glioma growth by directly phosphorylating p70S6K at T389. Taken together, we found a new mTOR-independent p70S6K activation pathway, Fyn-YANK2-p70S6K, which promotes glioma growth, and YANK2 is a potential oncogene and serves as a novel therapeutic target for glioma.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2045-2322
Relation: https://doaj.org/toc/2045-2322
DOI: 10.1038/s41598-024-61157-5
URL الوصول: https://doaj.org/article/b1328a75ecbb4873a1bf6cb7693fa954
رقم الأكسشن: edsdoj.b1328a75ecbb4873a1bf6cb7693fa954
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20452322
DOI:10.1038/s41598-024-61157-5