دورية أكاديمية
Depressive symptoms exacerbate disability in older adults: A prospective cohort analysis of participants in the MemAID trial
| العنوان: | Depressive symptoms exacerbate disability in older adults: A prospective cohort analysis of participants in the MemAID trial |
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| المؤلفون: | Stephanie S. Buss, Laura Aponte Becerra, Jorge Trevino, Catherine B. Fortier, Long H. Ngo, Vera Novak |
| المصدر: | PLoS ONE, Vol 17, Iss 11 (2022) |
| بيانات النشر: | Public Library of Science (PLoS), 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | Background Maintaining independence in older age is an important aspect of quality of life. We investigated depressive symptoms as an important modifiable risk factor that may mediate the effects of physical and cognitive decline on disability. Methods We prospectively analyzed data from 223 adults (age 50–85; 117 controls and 106 with type-2 diabetes) over 48 weeks who were participating in a clinical trial “Memory Advancement by Intranasal Insulin in Type 2 Diabetes.” Data from self-reported disability (World Health Organization Disability Assessment Schedule) and depressive symptoms (Geriatric Depression Scale) were obtained from baseline, week 25, and week 48 visits. Cognition (Mini-mental status examination) and medical comorbidities (Charlson Comorbidity Index) were assessed at baseline. Longitudinal analysis assessed the extent to which change in depressive symptoms predicted worsening disability. Mediation analyses were performed to determine the extent to which depressive symptoms accounted for disability associated with worse cognition, walking speed, and comorbidities. Results At baseline, depressive symptoms, cognition, and walking speed were within normal limits, but participants had a high 10-year risk of cardiovascular mortality. Depressive symptoms were related to disability at baseline (pConclusions Depressive symptoms substantially exacerbated the effects of worsening cognition, gait speed, and comorbidities on disability. In our sample, most individuals scored within the “normal” range of the Geriatric Depression Scale, suggesting that even subclinical symptoms can lead to disability. Treating subclinical depression, which may be under-recognized in older adults, should be a public health priority to help preserve independence with aging. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1932-6203 |
| Relation: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9707770/?tool=EBI; https://doaj.org/toc/1932-6203 |
| URL الوصول: | https://doaj.org/article/aab16cf8adec424c82b803997c88c823 |
| رقم الأكسشن: | edsdoj.b16cf8adec424c82b803997c88c823 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19326203 |
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