دورية أكاديمية
Neuroendocrine differentiation in prostate cancer
| العنوان: | Neuroendocrine differentiation in prostate cancer |
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| المؤلفون: | Cerović Snežana J., Brajušković Goran R., Maletić-Vukotić Vinka D., Mićić Sava R. |
| المصدر: | Vojnosanitetski Pregled, Vol 61, Iss 5, Pp 513-518 (2004) |
| بيانات النشر: | Military Health Department, Ministry of Defance, Serbia, 2004. |
| سنة النشر: | 2004 |
| المجموعة: | LCC:Medicine (General) |
| مصطلحات موضوعية: | carcinoma, neuroendocrine, prostatic neoplasms, tumor markers, biological, prostate-specific antigen, Medicine (General), R5-920 |
| الوصف: | Background. In numerous recent studies attention has been focused to neuroendocrine differentiation (NED) in prostate cancer (PC). Focal NED is present in almost all PCs, but it is prominent in only 5-10% of the carcinomas. The prognostic significance of focal NED in PC is controversial, but current evidence suggests its influence on the onset and/or conversion of hormon resistant tumor phenotype. The aim of this study was to evaluate the relationship between NED status, based only on immunohistochemical use of neuroendocrine (NE) markers, with PC grade and stage, and preoperative serum levels of prostate-specific antigen (PSA). Methods. The study included the biopsy material of 73 untreated PC patients (pts.) obtained by transurethral resection (TUR) (37 pts.), and radical retropubic prostatectomy (RRP) (36 pts.). Two representative tissue samples (tipically the block containing the largest amount of neoplasm) were selected for immunohistochemical (IMM) staining. NE cells were identified using a panel of IMM markers: chromogranin A, neuron-specific enolase, and serotonin. The level of PC exocrine differentiation was detected by monoclonal antibodies against PSA. Results. Significant expression of NE cells was demonstrated in 26 (70.2%) pts. with PC after TUR. In this group, serum preoperative PSA values ranged from 0.1 to 9.6 ng/ml. The majority of pts. with NED had low differentiated PC with Gleason grade score (GGS) >7, and normal PSA values below 4 ng/ml (77%), in clinical stage D (54%). Statistically significant correlation (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Serbian |
| تدمد: | 0042-8450 |
| Relation: | https://doaj.org/toc/0042-8450 |
| DOI: | 10.2298/VSP0405513C |
| URL الوصول: | https://doaj.org/article/cdb184bb74754fd8b14da2ad85ead539 |
| رقم الأكسشن: | edsdoj.b184bb74754fd8b14da2ad85ead539 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 00428450 |
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| DOI: | 10.2298/VSP0405513C |